What Is the Serotonin Receptor?

Serotonin receptors, also known as serotonin receptors or 5-HT receptors, are a group of G protein-coupled receptors and ligand-gated ion channels that appear in the central nervous system and around the peripheral nervous system. They regulate the transmission of both excitatory and inhibitory neurotransmitters.

Serotonin receptor

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Serotonin receptors, also known as serotonin receptors or 5-HT receptors, are a group of G protein-coupled receptors and ligand-gated ion channels that appear in the central nervous system and around the peripheral nervous system. They regulate the transmission of both excitatory and inhibitory neurotransmitters.

Serotonin receptors, also known as serotonin receptors or 5-HT receptors, are a group of G protein-coupled receptors and ligand-gated ion channels that appear in the central nervous system and around the peripheral nervous system. They regulate the transmission of both excitatory and inhibitory neurotransmitters.

Serotonin receptors can be divided into seven subfamilies 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7. At least fourteen receptor subtypes have been discovered, including G protein-coupled receptors and a ligand-gated ion channe.

The 5-HT1 receptor is the largest family of 5-HT receptor families. There are currently five subtypes of A, B, D, E, and F, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT1F five receptor proteins. There is no 5-HT1C receptor because it is reclassified as a 5-HT2C receptor.

The 5-HT2 receptor subfamily includes three subtypes of A, B, and C, 5-HT2A, 5-HT2B, and 5-HT2C.

5-HT3 receptor

5-HT4 receptor

The 5-HT5 receptor subfamily includes A, B, and 2 subtypes, and 5-HT5A and 5-HT5B receptor proteins.

5-HT6 receptor

5-HT7 receptor

There are a total of fourteen receptor subtypes.

With the exception of the 5-HT3 receptor, which is a ligand-gated ion channel, all other serotonin receptors are G protein-coupled receptors that activate a second messenger in the cell to produce an effect. In 2014, a new 5-HT receptor was discovered in the cabbage cabbage butterfly genome, named pr5-HT8. It has low similarity to various known 5-HT receptors, and there is no similar gene in mammals.

Serotonin receptors (or serotonin receptors) are located on the cell membranes of animal nerve cells and other cell types, and mediate the role of serotonin as an endogenous ligand and a wide range of drugs and hallucinogenic drugs. With the exception of the 5-HT3 receptor, the ligand-gated ion channel (LGIC), all other serotonin receptors are G protein-coupled receptors (GPCRs), which activate the second intracellular messenger cascade. (Also known as the seven-transmembrane receptor or the helix helix receptor).

Serotonin receptors are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGIC) found in the central and peripheral nervous systems. They mediate both "excitatory" and "inhibitory" neurotransmissions. Serotonin receptors are activated by the neurotransmitter "serotonin", which acts as their natural ligand.

Serotonin receptors regulate many neurotransmitters, including glutamate, gamma-aminobutyric acid (GABA), dopamine, epinephrine / norepinephrine and acetylcholine, as well as many other hormones, including oxytocin, prolactin, pressure Hormones, cortisol, corticotropin and substance P, etc. Serotonin receptors affect various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep and body temperature regulation. Serotonin receptors are the targets of many drugs, including many antidepressants, antipsychotics, anorexia, antiemetics, gastrokinetics, and antimigraine drugs.

Serotonin receptors are found in almost all animals and humans, and are even known to regulate longevity and behavioral aging in primitive nematodes, Caenorhabditis elegans.