What Are the Stages of Lung Cancer Progression?

Lung cancer bone metastasis refers to the transfer of lung cancer cells to the corresponding bones through blood. Bone is a common site of lung cancer metastasis. The incidence of lung cancer bone metastasis is related to the location and pathological type of the primary cancer. Adenocarcinoma has the highest incidence of bone metastasis, followed by small cell lung cancer and squamous cell carcinoma. The metastatic lesions are mainly multiple. The most common sites are: ribs, thoracic spine, lumbar spine, and pelvis; adenocarcinoma is mainly metastatic to the chest and pelvis. Bone metastases from lung cancer are mainly adenocarcinoma, and often invade ribs and thoracic spine. The reason may be that adenocarcinoma occurs in the periphery of the lung, which is likely to cause direct invasion and involve the ribs and thoracic spine. In addition, tumor cells reach the bones through blood circulation, and are also easy to grow and reproduce on the trunk bone containing red bone marrow, but less on the long bones of the limbs containing yellow bone marrow.

Bone metastases from lung cancer

Lung cancer bone metastasis refers to the transfer of lung cancer cells to the corresponding bones through the blood. Bone is a common site for lung cancer metastasis.

Bone metastases are generally asymptomatic in the early stages, and bone isotope scans can reveal diseased bones. Bone metastases symptoms and

1. Radionuclide bone scan (

Bone metastases from lung cancer are mostly osteolytic destruction,

Bone metastases from lung cancer

In clinical practice, the most common metastatic site of lung cancer is bone. Especially for small cell lung cancer and poorly differentiated non-small cell lung cancer, the incidence rate is about 30%. Spinal bones, ribs, and pelvic bones are more common, and limbs are rare. The symptoms of bone metastases in early lung cancer are not obvious, and pain is the most prominent of the symptoms of bone metastases in advanced lung cancer. From bone metastasis to clinical pain, it usually takes more than 1 year. Symptoms of bone metastases in lung cancer are fixed in position and pain gradually worsened at night; thoracic spine metastases can cause band-like pain; lumbar spine metastases often occur with radiation pain along the outside of the lower limbs to the outside of the feet, which increases with cough and defecation. Sciatica similar to osteoporosis or disc herniation should be vigilant.

Because bone metastasis of lung cancer is mainly osteolysis, pathological fractures and hypercalcemia sometimes occur. The most commonly used clinical examination is isotope bone scan, which can quickly show the bone metastasis of the whole body, with high sensitivity, but its specificity Lower; MRI and CT can show local conditions of bone metastasis, so specificity and localization are better than bone scan, especially local MRI is more superior than CT. X-ray films are less sensitive and can only be displayed when the osteolytic lesion is greater than 1 cm. However, because it still has advantages over flat bones and is inexpensive, X-ray films of these parts are still commonly used for inspection.