What is Cholestasis of Pregnancy?
Intrahepatic cholestasis of pregnancy is a unique complication in the middle and late stages of pregnancy. ICP has a small effect on the pregnant woman. Itchy skin without skin lesions often appears in the third trimester, sometimes with mild jaundice, few other symptoms, serum biochemistry. In terms of indicators, it caused mild and moderate elevation of transaminase and bilirubin and elevation of glycylic acid, and some pregnant women experienced postpartum hemorrhage; however, ICP has a greater impact on the fetus, which can cause fetal distress, sudden unpredictable fetal death in the third trimester, Neonatal intracranial hemorrhage, neonatal nervous system sequelae, etc.
- Chinese name
- Cholestasis of pregnancy
- Foreign name
- intrahepatic cholestasis of pregnancy, ICP
- Intrahepatic cholestasis of pregnancy is a unique complication in the middle and late stages of pregnancy. ICP has a small effect on the pregnant woman. Itchy skin without skin lesions often appears in the third trimester, sometimes with mild jaundice, few other symptoms, serum biochemistry. In terms of indicators, it caused mild and moderate elevation of transaminase and bilirubin and elevation of glycylic acid, and some pregnant women experienced postpartum hemorrhage; however, ICP has a greater impact on the fetus, which can cause fetal distress, sudden unpredictable fetal death in the third trimester, Neonatal intracranial hemorrhage, neonatal nervous system sequelae, etc.
Causes and common diseases of cholestasis of pregnancy
- Refers to the normal amount of bile can not enter the intestine, can be caused by a variety of causes, such as changes in liver cell membrane, microbiliary membrane and tight junction changes. Pathological changes vary with time and etiology. The macroscopic view of the liver often enlarges, the color turns green, and the swelling is obvious at the edge. Nodules may appear in further development. The clinical manifestations are mainly jaundice, pruritus, dark urine, and pale stools that are characteristic of cholestasis.
Differential diagnosis of cholestasis of pregnancy
- The symptoms of pruritus and impaired liver function with elevated serum aminotransferase and bile acid levels are the two basic conditions for the diagnosis of ICP; in addition, there are jaundice, diarrhea, yellow urine, and pain in the liver area.
Cholestasis of pregnancy
- Prenatal examinations routinely ask for skin sputum, and carefully check for skin scratches. At the same time, pay attention to the atypical manifestations of early ICP, such as elevated liver enzymes, jaundice symptoms, diarrhea, yellow urine, and pain in the liver area, so as to promptly Discover ICP.
Cholestasis in pregnancy treatment principles
- Nowadays, most of the drugs used in the treatment of intrahepatic cholestasis of pregnancy (ICP) are mainly symptomatic. Commonly used western medicines include phenobarbital, dexamethasone, S-adenosylmethionine, and ursodeoxycholic acid. , But the treatment effect is not satisfactory, and some drugs pose a certain threat to the safety of mothers and children, patients with poor compliance. Based on its unique theoretical basis, Chinese medicine explains the pathogenesis of ICP from the perspective of kidney-reproduction, spleen-transportation, and liver-relief. The methods of tonifying kidney and dampness, strengthening the spleen, helping the liver, and clearing away heat and liver can also be used to treat ICP. Significantly improve the symptoms of patients, reduce serum bile acid levels and the incidence of fetal complications, in recent years have attracted the attention of scholars at home and abroad, but research on these traditional Chinese medicines and their prescriptions is still in its infancy.