What Is Indirect Bilirubin?
Indirect bilirubin is also called unconjugated bilirubin, that is, bilirubin that does not bind to glucuronic acid. Total bilirubin is composed of indirect bilirubin and direct bilirubin. Serum indirect bilirubin elevation is mainly related to various hemolytic diseases. After the destruction of a large number of red blood cells, a large amount of hemoglobin is converted into indirect bilirubin, which exceeds the processing capacity of the liver, and it cannot be fully converted into direct bilirubin, which increases the indirect bilirubin in the blood. Its concentration reflects the transformation function of hepatocytes and the decomposition status of red blood cells.
Basic Information
- Chinese name
- Indirect bilirubin
- Foreign name
- Indirect Bilirubin
- English abbreviations
- I-Bil
- Reference
- 3.4-17.0 mol / L
- Features
- Increased indirect bilirubin, hemolytic jaundice
Clinical significance of indirect bilirubin
- Liver disease
- Certain malignant diseases can also cause high indirect bilirubin in the blood, such as acute jaundice hepatitis, acute liver necrosis, chronic active hepatitis, and cirrhosis.
- 2. Hemolytic anemia
- A large number of red blood cells are destroyed in the human body. When there is too much indirect bilirubin in the blood, it exceeds the conversion capacity of the liver, causing indirect bilirubin to stay in the blood, which causes the indirect bilirubin in the blood to be high. For hemolytic jaundice, patients usually have yellow skin, yellow sclera, and yellow urine.
- 3. Incompatible blood transfusion
- When blood of incompatible blood type is input, it will cause hemolysis, which will destroy a lot of red blood cells in the body, which will cause high indirect bilirubin in the blood.
- 4. Hepatocellular jaundice
- When liver cells become diseased, either because bilirubin cannot be normally converted into bile, or due to swelling of the liver cells, the bile ducts in the liver are compressed, the excretion of bile is blocked, and the bilirubin in the blood is increased.
- 5. Other
- Severe burns, sepsis, malaria, hypersplenism, malignant anemia, globin production anemia, lead poisoning, neonatal physiological jaundice, drug-induced jaundice, constitutional jaundice, breastfeeding jaundice, etc.
Indirect bilirubin reference value range
- 1.7 to 10.2 moL / L.
Indirect bilirubin considerations
- Take 1ml of fasting venous blood, place it in the red or yellow cap procoagulant tube to protect from light, and send it for inspection in time. Rejection of hemolytic and lipemia specimens.