What is lymphopoiesis?
In immunology, white blood cells can be classified as polymorphonuclear neutrophils, polymorphonuclear basophils, polymorphonuclear eosinophils, monocytes, lymphocytes or plasma cells. Lymphopoiesis is a process of lymphocyte production such as B cells, t cells and natural killer cells, in the bone marrow. In this process, progenitor cells in the bone marrow are differentiated to lymphocytes. Lymphopoiesis is essential for survival because ripe lymphocytes are the basic elements of the lymphatic system of the body. Non -differentiated cells, called pluripotential hematopoietic stem cells, can undergo a number of cellular divisions and differentiation in the bone marrow before either committing red blood cells, myelocytes or lymphocytes. In the lymphopois, a pluripotential hematopoietic stem cell gives rise to a multipotent progubuna nitor. This cell causes early lymphoid progenitor, which in turn leads to a conventional lymphoid progenitor (CLP). Common lymphoid progenitor can cause natural killers (NK)Cells, dendritic cells and proshymphocytes. T cells in the thymus remain in an environment without an antigen for almost 1 week. In this environment, only 2 to 4% of the original T cell population are able to survive.
other T cells are either subject to apoptosis or are consumed and destroyed by macrophages. The death of this large amount of T lymphocytes ensures that surviving lymphocytes can recognize complexes of histocompatibility (MHC). Recognition of this complex prevents autoimmune destruction of the body cells. The cells or tymocytes can differentiate to auxiliary t (th) cells, cytotoxic t (TC) cells, memory t cells and suppressor or regulatory t cells.
Lymphopoiesis B cells are originally formed in the bone marrow. When bone marrow is disturbed, this function could take over the spleen. The first studies on B cells were performed on the Fabricsus exchange present in chickens and are therefore called B cells. After the creation of JSOU B BUNS BY LYMFATIC NOPS AND INTRODED INTO ACCOUNTS.
Antigen recognition is an important function of B cells. Once the B cell recognizes the antigen, it becomes activated and is distinguished into a plasma cell, a cell -secreting cell. Antibodies bind antigen and stimulate destructive mechanisms such as complement and phagocytosis of macrophages. The most common antibody is immunoglobulin G (IgG). Other antibodies such as immunoglobulin and (IgA), immunoglobulin E (IgE) and immunoglobulinm (IgM) can also be made by ripe B cells.