What is the connection between telomerase and cancer?
telomerase, enzyme involved in DNA replication, plays an important role in the development of cancer and seems to explain why cancer cells are so aggressive. The connection between telomerase and cancer is interesting because it provides information on how cancer persists when cells should stop growing, and also offers insight into potential treatments. Focusing on these medicines, the doctor could stop the growth of cancer cells in their footsteps using telomerase and cancer.
In normal cells comes the replication of DNA at costs. Enzymes that duplicate chromosomes cannot run at the end of DNA chains. This would result in a constant crop of genetic material and subsequent DNA degradation with each cell division. The sections known as telomers are with this problem by providing a number of repetitions at the ends of chromosomes. Cutting some repetitions does not damage the coding DNA in the core of the core.
Every time the cells are divided, telometers are shortened, even with telomerase present in the cell to add repetitions during divisions to make DNA as stable as possible. Finally, cells can no longer replicate reliably and the cell line is dying. The number of divisions that the cell is able to vary, and in the body at the moment, cells may have telomers of different lengths. This built -in aging is not just a recipe for aging. It also allows the body to turn off the cells because their DNA is damaged by multiple replications, because the slices are too short to reliably copy the DNA.
Scientists studying cancer have noted that tumor cells often contain these specific proteins. This has shown a clear link between telomerase and cancer, showing that tumor cells used an enzyme to become effectively immortal. Cancer cells usually have very short telomers, but the connection between telomerase and cancer ensures that telomers remain long enough to keep the cell replication, whatIt allows tumor growth.
6 They found that cancer cells began to produce telomerase after becoming malignant. This explains why their telomers in the first place, because the enzyme is not present to add repetition during cell division initially. Once the cells begin to get out of control and lose replications that would normally kill malignant cells, they use telomerase for constant growth.