What Is the Connection Between Telomerase and Cancer?

Telomerase , an enzyme responsible for telomere elongation in cells, is a basic nucleoprotein reverse transcriptase that adds telomere DNA to the end of chromosomes in eukaryotic cells and fills in telomeres that are lost in DNA replication. Together, prolonging the repair of telomeres can prevent telomeres from being lost due to cell division, which increases the number of cell divisions. Telomeres play an important role in maintaining chromosomal stability and cell viability in cells of different species. Telomerase can lengthen shortening telomeres (shortened telomeres have limited cell replication ability), thereby enhancing the ability of cells to proliferate in vitro. Telomerase activity is inhibited in normal human tissues and reactivated in tumors, possibly participating in malignant transformation. Telomerase plays an important role in maintaining telomere stability, genome integrity, long-term cell activity, and potential for continued proliferation. The existence of telomerase is to fill in the defects of DNA replication, that is, by extending the repair of telomeres, the telomeres will not be lost due to cell division, which will increase the number of cell divisions.

Telomerase

Telomerase , an enzyme responsible for elongation of telomeres in cells, is a basic nuclear protein

Can people solve problems with telomerase?

The aging mechanism (link) The first question to be clear is why people die, only for this process

American scientists have recently discovered a protein that functions much like telomerase. It can transport vital protein blocks around to repair the ends of chromosomes that are lost during normal replication. Without such routine maintenance,

Telomerase activity and the occurrence and mechanism of colorectal tumors. Colorectal tumor cells divide faster and telomerase activity is higher; while tumor cells with slower cell division have lower telomerase activity. In the normal human body, there are complex mechanisms that inhibit the unlimited proliferation of cells: one is the periodic control of cells; the other is the apoptosis or programmed death caused by the progressive shortening of telomeres with each cell division. Telomerase activity was positively correlated with the survival time of colorectal tumor cells in effusion. Telomerase activity is an important indicator for early diagnosis and prognosis of colorectal cancer. Detection of telomerase activity from stool cells can be used as a non-invasive early diagnosis method for colorectal cancer. Xingtai No. 4 Hospital can detect telomerase activity by using polymerase chain telomere repeat amplification (PCR TRAP) silver staining technology.