What is the Fluorescent in Situ Hybridization Technique?

Fluorescence in situ hybridization (FISH). The fluorescently labeled specific nucleic acid probe is used to hybridize with the corresponding target DNA molecule or RNA molecule in the cell. The fluorescence signal is observed under a fluorescence microscope or a confocal laser scanner to determine the cells or cells that are stained after hybridization with the specific probe The shape and distribution of organelles, or the location of DNA regions or RNA molecules in chromosomes or other organelles combined with fluorescent probes.