What Is the Purpose of Endotoxin Removal?
Gram-negative bacteria (such as typhoid, tuberculosis, dysentery, etc.) in the bacterial body of the toxic substances present in the general term. It is a cell wall component of a variety of Gram-negative bacteria. The toxin released after lysis by the bacteria is also called "pyrogen". The unit is Eu / ml. Its chemical composition is a phospholipid polysaccharide-protein complex, and its toxic component is mainly lipidoid A. Endotoxin is located on the outermost layer of the cell wall, covering the mucosin of the cell wall. The toxic effects of endotoxins of various bacteria are relatively weak, which are about the same, and can cause fever, microcirculation disorders, endotoxin shock, and disseminated intravascular coagulation. Endotoxin is heat-resistant and stable, and has weak antigenicity. It can stimulate the body to produce antibodies, but it has no neutralizing effect and forms antitoxins. It cannot become toxoid after formaldehyde treatment.
Endotoxin
- Because endotoxin is caused by bacterial death, lysis or autolysis, endotoxin is abundant in the environment. Endotoxin is not harmful when it passes through the digestive tract of the body. A small amount of it is inactivated by the liver's Kupffer cells after entering the blood by injection. It does not cause body damage. Endotoxin enters the blood in large quantities and causes a fever reaction "
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- 1. The most accurate temperature control: When the ambient temperature is 15-30 ° C and the humidity is 40-60%, the detector temperature is controlled at 37 ° C ± 0.5 ° C.
- 2. The most sturdy body: The overall design, no moving components, components are not easy to damage, the body runs stably for a long time, the instrument does not need frequent calibration, and the maintenance cost is low.
- 3. The most sensitive plutonium reagent: The detection sensitivity of the plutonium reagent using the turbidimetric method can reach 0.001 EU / ml, and the test results can retain 2-4 significant digits.
- 4. Lowest amount of thallium reagent: The amount of thallium reagent used is only 0.05ml, which can double the cost savings.
- 5. The most realistic temperature display: real-time temperature detection, the temperature can be stabilized at the whole 37 in 80% of the time.
- 6. The most convenient test procedure: only one negative test and one positive test are required each day, and only one standard curve is required for each lot of rhenium reagent, which effectively saves costs and simplifies operations.
- 7. The most powerful detection capability: 96 detection wells, each well is independent, users can establish 96 detection schemes at the same time.
- 8. The most authoritative detection system: This system is the world's recognized authoritative system. It is a leader in the field of endotoxin detection. The result report can be used for FDA declaration.
- Software features:
- 1. The operation interface is simple and fast, and the function is rich. The user only needs to make simple settings when using it for the first time.
- 2. It can save the setting, test plan, test result and standard curve, and can save the saved file at any time. The saved file can be named automatically or manually.
- 3. The detection scheme can be set in batches, and the standard curve is set once to automatically mark all points.
- 4. You can add, delete, and change the detection plan at any time (including the detection in progress).
- 5. Data analysis is performed automatically after the test is completed, and the previous data can also be opened for analysis.
- 6. Automatically draw the standard curve, including the correlation coefficient, slope, and intercept. The unqualified points can be removed, and the curve can be called at any time.
- 7. Automatic calculation of endotoxin content, sample recovery rate, correlation coefficient, coefficient of variation, and can automatically determine whether the test process and results are qualified.
- 8. In order to prevent system interruption due to power failure, the system automatically saves the data and settings before the interruption.
- 9. The system data and test results can be printed out and the report meets the US FDA requirements.
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