What Is Keratosis Follicularis?
Also known as false hair follicle keratosis. First named by Darier in 1889, it is also called Darier's disease. This disease is a rare chronic keratotic dermatosis with poor epidermal keratosis as the basic pathological change. Due to the tendency of skin lesions to fuse and proliferate, they were once called proliferative follicular keratosis and proliferative follicular keratosis.
- Also known as
- Dalier's disease, pseudofollicular keratosis, Darier's disease, proliferative follicular keratosis, proliferative follicular keratosis
- English name
- Darier'sdisease
- Visiting department
- dermatology
- Common locations
- Seborrhea
- Common causes
- Autosomal dominant inheritance
- Contagious
- no
Basic Information
Causes of follicular keratosis
- This disease is an inherited skin disease with abnormal keratinization caused by autosomal dominant inheritance. Some people think that vitamin A metabolism disorders and sunlight are important pathogenic factors.
Clinical manifestations of follicular keratosis
- The disease usually begins in the age of 20 to 30 years. Aggravated in summer, patients are sensitive to heat. Typical areas are seborrhea, such as small, firm, normal-colored small pimples on the face, forehead scalp, and chest and back, which gradually become oily, gray-brown, and black palate covering the concave surface of the top of the pimples, and the pimples gradually grow into warts. Fusion forms irregular plaques. The sweating and rubbing of the flexor axilla, gluteal sulcus, and femoral area are particularly significant. The papilloma-like and proliferative lesions with malodor are formed, which are covered with cleft palate, impregnation, and purulent exudate. The disease can include palmar plantar keratosis, hyperthyroidism of nails, nail fragility and fragmentation. It can also affect the oropharyngeal, esophagus, larynx, and anorectal mucosa.
Keratosis follicular examination
- The characteristic pathological changes of this disease are: poor keratinization of special morphology, forming round bodies and grains; the spinous layer on the basal layer loosens, forming fissures and crypts on the basal layer; nipples covered with a single layer of basal cells, not upward Regular hyperplasia enters the crypts and fissures; there may be papillomatous hyperplasia, spinous layer hypertrophy and hyperkeratosis, and chronic inflammatory infiltration of the dermis.
Hair follicle keratosis diagnosis
- Diagnosis is based on clinical manifestations and histopathology.
Keratosis follicularis treatment
- Patients should avoid direct sunlight. Mild patients do not need treatment, and can also be used topically as lubricants and retinoic acid preparations. Severe cases can be treated with retinoic acid. Close marriage is prohibited.