Is it okay to combine Lisinopril and Grapefruit?

can be used a combination of lisinopril and grapefruit. While grapefruit juice can interact with other medicines, it has not been reported that this is a problem with lisinopril. If one is not sure whether their drugs interact, either with each other or with food, they should talk to your doctor or pharmacist. They work by blocking the enzyme called angiotensin converting enzyme (ACR), which reduces the effect of angiotensin 2 and causes blood vessels to spread, reducing blood pressure. They can also reduce the heart load. Each medicine is subject to metabolism in different ways and is influenced by different factors. One of the systems involved in metabolism is the Cytochrome P450. Mattento system affects NY drugs and some foods or beverages such as grapefruit juice. Some may defend specific enzymes from the system while others can trigger them.

If the enzyme is inhibited, it mayt to reduce the disintegration of drugs that this enzyme normally metabolized, resulting in elevated levels and possible increase in therapeutic effect and adverse effects. On the contrary, the induction of the enzyme can lead to a faster decay of drugs, which normally metabolized with this enzyme, which does not nagrate or reduce its desired effect. It is known that grapefruit juice inhibits some enzymes involved in this system.

While Lisinopril and Grapefruit probably do not interact and can be used together, many other drugs can interact with grapefruit juice for its inhibitory effect and should avoid people who take them. Lisinopril and grapefruit do not fall into this group of doctors because Lisinopril's metabolism does not rely on enzymes that are blocked by grapefruit juice.

medicines that can interact with grapefruit juice include some cholesterol medicines such as statins such as atorvastatin; Some calcium channel blockers, useane for blood pressure and heart conditions that include felodipine and nicardipine; And some antiretroviral drugs, for people with HIV like Saquinavir. This is by no means a complete list of drugs that should not be taken with grapefruit juice. So, although there is probably no interaction between lisinopril and grapefruit, it may probably interact with other drugs used, including complementary, homeopathic and counter products. Advice should be obtained from a doctor or pharmacist about whether grapefruit juice should be avoided when taking some medicines.