Is it safe to combine celecoxib and alcohol?

Celecoxib is a painkiller that is in a family of drugs called non -steroidal anti -inflammatory drugs (NSAIDs). Like other NSAIDs, a combination of celecoxib and alcohol can be dangerous. For this reason, both healthcare professionals and drug manufacturers warn against mixing with alcohol, even if it is accepted at low doses. One danger comes from potential stomach damage, although this risk is not as large as other NSAIDs. Celecoxib, like other NSAIDs, suppresses inflammation in the body inhibiting a protein called cyclooxygenase-2 (COX-2), which is involved in an immune response. This medicine is largely focused on COX-2, unlike NSAIDs, such as ibuprofen, but there is some residual inhibition of related enzyme, Cox-1.

found in the stomach, Cox-1 helps to protect the stomach from its own acids. Even a small amount of inhibition can reduce stomach defense against damage. Alcohol can directly irritate stomach lining and promote the release of stomachAcid and further damage its surface. Combination of celecoxib and alcohol can cause stomach bleeding through these mechanisms. Celecoxib can essentially leave the stomach unable to protect against damage mediated by alcohol.

As mentioned, specific targeting COX-2 Cecoxib reduces the risk of stomach bleeding and ulcers, even if it does not exclude it. Drinking large amounts of alcohol, using large doses of drugs or involvement in both activities can increase the risk of adverse effects for a long time. The use of other NSAIDs, such as acetaminophene or ibuprofen with cell and alcohol, can also significantly increase the chances of harmful events.

Another possible risk from the Celecoxiba mixture Aalohol comes from the effects that each substance can have on the heart. NSAIDs like CeCoxib, which specifically focus on Cox-2 enzyme, have a better chance of leading to major cardiovascular problems, including strokes and heart attacks. Drinking can also lead to cardiovascular problems, such as a condition that enlarges the heart, which also increases the risk of serious side effects, which may also include heart attacks and strokes. Further research should be carried out on individuals who have mixed celecoxib and alcohol, but from available evidence it seems that there is a possible risk that this combination will contribute to life -threatening heart problems.