What Are the Pros and Cons of Coenzyme Q10 for Blood Pressure?

Coenzymes are small organic molecules that can transfer chemical groups from one enzyme to another. They are loosely bound to the enzyme and are necessary for the activity of a particular enzyme. Many vitamins and their derivatives, such as riboflavin, thiamine, and folic acid, are coenzymes. These compounds cannot be synthesized by the human body and must be supplemented through diet. Different coenzymes can carry different chemical groups: NAD or NADP + carries hydrogen ions, Coenzyme A carries acetyl, folic acid carries formyl, and S-adenosylmethionine can also carry formyl.

Amex Coenzyme Q10

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Thiamine

That is vitamin B1. Its coenzyme form in the organism is

Acts as a cofactor for some enzymes. It is covalently linked via an amide bond to the epsilon-amino group of a specific lysyl residue of the apoenzyme protein. -N-biotinyl-L-lysine is called biocytin (Fig. 4 [the form of biotin as a prosthetic group]).

Enzymes that require biotin can catalyze the incorporation (carboxylation) or transfer of carbon dioxide, so biotin and carbon dioxide fixation are closely related. The presence of adenosine triphosphate (ATP) and magnesium ions is also required during carboxylation. In addition, biotin also plays an important role in protein biosynthesis and transamination.

Pantothenic acid

It was originally isolated as a growth factor for yeast. Because it is widely found in living things, it is called pantothenic acid. The coenzyme form of pantothenic acid is

Coenzyme Q10 is also known as ubiquinone 10 and decenone. It is a fat-soluble quinone compound that is widely present in organisms. Its structure is similar to that of vitamin K. Coenzyme Q10 from different sources has different numbers of side chain isopentene units. Humans and mammals have 10 isopentene units. The polyisoprenyl side chain on the sixth position of the mother core is named after having a degree of polymerization of 10.

Coenzyme Q10 is relatively high in foods such as organs (heart, liver, kidneys), beef, soybean oil, sardines, mackerel and peanuts. Ingesting about 1 kg of sardines, 2 kg of beef, or 3 kg of peanuts can provide about 30 mg of Coenzyme Q10, respectively.

Coenzyme Q10 was discovered in 1957, and its chemical structure was identified by Dr. Caru Flucas in 1958, and received the highest honor of the American Chemical Society Priestly Medal, known as the father of coenzyme Q10. At the time, he proposed coenzyme Q10 It plays an important role in cardiac function. In real life, Dr. Carru Forukas, who has been taking Q10 for almost 40 years, until his death at the age of 91, he has been an active professor engaged in scientific research activities.

The physiological role of coenzymes in the body

Coenzyme Q10 quinone ring plays the role of transferring electrons and protons in the oxidative respiratory chain. This role is not only essential for all life forms, but also the key to the formation of ATP. ATP is the main storage form of the body's energy and an important basis for the normal functioning of all cellular functions. The biological activity of coenzyme Q10 mainly comes from the redox properties of its quinone ring and the physicochemical properties of its side chains.

There are two main functions in the body. One is to play an important role in the process of nutrients being converted into energy in the mitochondria. It promotes oxidative phosphorylation in the proton shift and electron transfer in the respiratory chain in the body. And cell metabolism activators; secondly, it has obvious anti-lipid peroxidation effect. Coenzyme Q10 has the functions of protecting the structural integrity of membranes and stable membrane potential, and is an important antioxidant and non-specific immune booster.

People lacking CoQ10 (CoQ10) usually suffer from heart failure, gum disease, arrhythmia, stroke, hypertension, heart attack, arteriosclerosis, muscle wasting, and AIDS. Coenzyme Q10 (CoQ10) can successfully prevent and treat these diseases, and since it was discovered and isolated more than 40 years ago, coenzyme Q10 has been clinically studied hundreds of times. A lot of evidence is now clear. This nutrient is necessary for health.

1) Antioxidant, application to the cardiovascular system

Coenzyme Q10 is mainly concentrated in the mitochondria of the heart muscle cells responsible for energy production. CoQ10 can help myocardial cells to generate energy, significantly increase myocardial oxygenation, have a good effect on improving the condition of heart failure, and can extend the life of myocardium. CoQ10 is also an antioxidant that can counteract the side effects of free radicals and low-density lipoproteins in the blood (low-density lipoproteins, the culprit causing myocardial infarction and stroke), and prevent arteriosclerosis. Moreover, its antioxidant properties make membranes stable, metabolically strong, and reverse left ventricular hypertrophy, which are widely used in cardiovascular disease.

Animal experiments have confirmed the following pharmacological effects: 1. It can reduce the weakening of myocardial contractility and the content of creatine phosphate and adenosine triphosphate during acute ischemia, maintain the mitochondrial morphology of ischemic myocardial cells, and have a certain protective effect on ischemic myocardium. . 2. Increasing cardiac output and reducing peripheral resistance are conducive to anti-heart failure treatment, which may inhibit the synthesis and secretion of aldosterone and block its effect on renal tubules. 3. When the isolated ventricular muscle is perfused under hypoxic conditions, the duration of action potential can be shortened, and the threshold of ventricular arrhythmia is higher than that of control animals. 4. This product also has anti-adriamycin cardiotoxicity and hepatoprotective effect.

Coenzyme Q10 is necessary for the heart and has attracted special attention in the prevention and treatment of various types of cardiovascular diseases. Several studies have shown that patients with congestive heart failure and patients with other cardiovascular diseases have significantly lower levels of coenzyme Q10 in their heart tissue than healthy people. And daily supplements of 100mg have been shown to significantly improve their condition .

Heart disease and stroke produce sudden free radicals (ischemic reperfusion), which can cause extensive tissue damage. Patients with higher coenzyme Q10 content suffer less from these conditions. Researchers in Japan have found that coenzyme Q10 supplementation before or immediately after cardiopulmonary bypass cardiac surgery is beneficial in preventing reperfusion damage, a common complication in cardiac surgery. Coenzyme Q10 supplementation has been found to be beneficial for patients with chronic stable angina, mitral valve prolapse, and irregular heartbeat (arrhythmia). Coenzyme Q10 has proven to be useful in the treatment of various cardiomyopathy (cardiac muscle disorders that reduce its pumping capacity). Studies have shown that supplementing 100 mg / day for 12 months can lead to better pumping capacity (increasing the rejection portion), increasing muscle strength and improving breathing.

CoQ10 is currently listed as the most precious heart health product in the ranks of health foods. It is popular in Europe, America and Japan, and is known as a panacea for protecting the heart. Coenzyme Q10 is currently approved in Japan for the treatment of congestive heart failure. It is the most widely used heart care agent in the Japanese medical community. CoQ10 can prevent and control myocardial infarction, myocardial failure, angina pectoris, and abnormal heartbeat because of its significant protective effect on the heart. CoQ10 is listed as a drug rather than a food in many countries.

2) Studies show that coenzyme Q10 is beneficial for treating hypertension

Significant research conducted by the Argentine Institute of Neuroscience has shown that in patients with hypertension, oral administration of 100 mg of coenzyme Q10 within one hour enhances brain treatment and agility.

A study of 109 patients with perennial essential hypertension taking antihypertensive drugs concluded that an average 225mg / day supplement with coenzyme Q10 improved functional status and caused half of patients to stop most of their blood pressure medications Treatment resulted in an average reduction in systolic blood pressure from 159 to 147 mmHg and diastolic blood pressure from 94 to 85 mmHg. Japanese studies have confirmed these findings. Research from the University of Aucona in Italy has provided evidence that supplementation with coenzyme Q10 reduces the levels of adrenaline and other catecholamines. This is considered partly responsible for the drop in blood pressure. It may also explain why coenzyme Q10 is effective in reducing the occurrence of certain types of arrhythmias.

3) Anti-aging

Harman elaborated the relationship between mitochondrial function and aging in 1972. The latest report on the role of mitochondrial aging in the aging process of the body argues that oxygen radicals damage mitochondrial DNA 16 times more than nuclear DNA. The reason may be that DNA in the mitochondrial matrix is more accessible to endogenous oxygen free radicals, and the DNA repair mechanism in the mitochondria is far inferior to nuclear DNA. Therefore, it is inferred that the subunits of mitochondrial DNA are increased by free radical damage with age.

In the early 1980's, Ernster of Sweden revealed the antioxidant and free radical scavenging effects of the vitamin-like substance CoQ10.

Experiments on the relationship between aging and mitochondrial coenzyme Q10 concentration have shown that a decrease in mitochondrial coenzyme Q10 concentration is an important aspect of skeletal muscle aging. An experimental study of aging in rats showed that mitochondrial coenzyme Q10 levels were reduced in the heart of aging rats, and that in the liver and skeletal muscle was lower. The decline in immune function with age is the result of free radicals and free radical reactions. Coenzyme Q10 is an effective antioxidant and free radical scavenger. As a component of the mitochondrial respiratory chain, it is embedded in the lipid bilayer of the mitochondrial inner membrane. It becomes 2 electrons received from mitochondrial complex I or complex II. Alcohol type, and then transfer electrons to complex III. And can regenerate vE, alone and in conjunction with vE to play the role of antioxidants. Coenzyme Q10 in the body is consumed in large amounts and becomes alcoholic. It is both an effective antioxidant and an electron carrier for movement. It transfers hydrogen atoms from its hydroxyl groups to lipid peroxidation free radicals, thereby reducing the lipid content of the mitochondrial inner membrane. Oxide reaction. In this process, a radical ubiquinone that is disproportionate to the alcoholic form of coenzyme Q10, or reacts with oxygen to form a superoxide. The radical ubiquinone is under the action of superoxide dismutase and catalase Transporting free radicals to achieve detoxification, so the reciprocating breathing chain continuously regenerates coenzyme Q10 into an alcoholic form, restoring its antioxidant activity.

4) Antitumor effect and immune regulation effect

Recent studies have shown that coenzyme Q10 has anti-tumor effects and has clinical efficacy for advanced metastatic cancer. In vitro experiments found that antioxidant coenzyme Q10 can protect mammalian cells from mitochondrial oxidative stress-induced apoptosis, while tumor necrosis factor- (TNF-) or oncogene inhibitors have no such effect.

Studies in Denmark have shown that in trials involving 32 breast cancer patients, large doses of vitamins, minerals, essential fatty acids and coenzyme Q10 (90mg / day) , added to conventional treatment, have shown that The beneficial effects of higher supplements. In the trial, two patients with no tumor regression had their coenzyme Q10 doses increased to 390 mg / day , respectively. As a result, their tumor completely disappeared within three months.

Coenzyme Q10 supplementation is also important for cancer patients undergoing chemotherapy for cardiotoxic drugs like doxorubicin and thresholds.

The decline in immune function with age is the result of free radicals and free radical reactions. Coenzyme Q10, as a strong antioxidant, can be used alone or in combination with vitamin B6 (pyridoxine) to inhibit free radicals from affecting immune receptors and cells Modifications of differentiation and activity-related microtubule systems enhance the immune system.

5) Coenzyme Q10 helps fight skin wrinkles and delay skin aging

The increase of wrinkles and the aging of the skin are related to the Q10 content. The lower the content, the easier the skin is aging, and the more the facial wrinkles are. Q10 can be ingested through makeup. When the cell contains enough Q10, energy metabolism will be enhanced, free radicals will be eliminated, and wrinkles will be relieved.

There are approximately 60 trillion cells in the human body. Coenzyme Q10 is present in every cell and is an indispensable component of cell activity, also known as cell energy. Coenzyme Q10, 24 hours a day without sleep, is the source of power for making collagen, hyaluronic acid, moisture, etc. that makes skin plump and tender. Coenzyme Q10 in skin epidermal cells is 10 times more than in dermis. Coenzyme Q10 decreases with age, and once the cell energy decreases, it becomes weaker, producing wrinkles, relaxation, and stains. Coenzyme Q10 skin care products deliver energy to the skin from the outside, so that each cell is full of energy, supporting the weakening cells one by one, making each cell plump and filling, and locking the skin to youthful redness. Coenzyme Q10 is an ingredient that gradually decreases with age, so it is especially important to supplement it with daily care. Coenzyme Q10 has excellent antioxidant effects, can inhibit the cause of fine lines-the damage caused by active oxygen, promote the metabolism of skin cells, and improve dry and rough skin. Dr. Hope's research team has also published a specific report on "Coenzyme Q10 has an improvement effect on wrinkles." Twenty middle-aged and elderly volunteers applied Coenzyme Q10 to the eyes every day. After 6 months, the depth of fine lines was reduced by about 27% and the area was reduced by about 28%. Therefore, it can be proved that Coenzyme Q10 can inhibit the production of coenzymes that break down collagen It can maintain the skin's richness and elasticity. In addition, it can increase the content of hyaluronic acid, a moisturizing ingredient, and improve the moisturizing effect of the skin. In addition, Coenzyme Q10 can also promote metabolism, regulate the normal operation of the skin regeneration cycle, keep the skin young, and keep away from various skin problems.

Local experiments have shown that skin collagen's ability to resist damage from oxidative irritants such as ultraviolet rays decreases with age, and long-term use of coenzyme Q10 can effectively prevent skin aging and reduce wrinkles around the eyes, as coenzyme Q10 penetrates into the skin growth layer can weaken The photon oxidation reaction, with the assistance of tocopherol, can start specific phosphorylated tyrosine kinases, prevent oxidative damage to DNA, inhibit the expression of collagenase in human skin fibroblasts under ultraviolet light, and protect the skin from damage . Extensive research suggests that coenzyme Q10 inhibits lipid peroxidation, reduces the generation of free radicals, protects SOD active centers and their structures from free radical oxidative damage, improves enzyme activities such as SOD in the body, and inhibits oxidative stress-induced apoptosis , Has a significant role in anti-oxidation, delay aging.

Coenzyme Q10 has attracted much attention in the cosmetics industry because it not only has the effect of maintaining the youthful state of the skin, but also, as Dr. Hope's experiments have proven, it can reduce the aging of fine lines and other skin damage.

Although coenzyme Q10 is easily absorbed by the body, it can be metabolized quickly because it can promote metabolism, so it needs to be supplemented daily. Coenzyme Q10 is added to skin care products for this reason. Remember to actively supplement your skin with CoQ10. Co-enzyme Q10 can be supplemented with skin care and balanced diet, health products, etc., which can further enhance the beauty effect.

6) Chronic fatigue syndrome

The etiology and pathology of chronic fatigue syndrome (CFS) is still unclear. Recent studies have shown that oxidative stress is a cause of the disease. Experiments have found that patients with CFS have varying degrees of oxidative stress. Whether the injury is the cause or the result of the disease requires further observation, but the antioxidant coenzyme Q10 has been successfully used to prevent and treat chronic fatigue syndrome.

In the mid-1970s, Mitchell's theory of chemical penetration hypothesis revealed the important role of energy conversion in the body and coenzyme Q10 in the mitochondrial energy conversion system.

Coenzyme Q10 improves energy and brainpower. Experiments have shown that coenzyme Q10 can greatly promote heart health, and an appropriate amount of coenzyme Q10 in the human body is necessary for proper muscle function. Biochemical analysis of muscle cell extracts revealed that when the concentration of coenzyme Q10 was lower than 20% of normal, its mitochondrial complex I + II and complex I + III activities were severely decreased. Several studies have clearly shown that coenzyme Q10 supplementation at 100-150 mg / day can significantly improve the condition of people suffering from muscular dystrophy. Hard physical exercise reduces the blood content of CoQ10, and a daily supplement of 60mg has been found to improve athletes' skills. The role of coenzyme Q10 can accelerate the metabolism of fat, make the limbs and the brain abundant in energy supply and energetic.

7) statins

Statins also inhibit the production of coenzyme Q10 in the body while inhibiting cholesterol synthesis.

Coenzyme Q10 deficiency is more likely to occur in elderly patients. When using statins, be sure to add 100 mg of coenzyme Q10 at the same time. Can quickly relieve myalgia and fatigue caused by statins, offsetting myalgia and liver damage associated with statins.

8) Clinical treatment effect

Clinical studies have shown that oral coenzyme Q10 has a significant effect on the treatment of neurodegenerative diseases related to mitochondrial dysfunction and aging, such as Parkinson's syndrome, Huntington's disease, and Alzheimer's disease .

9) Coenzyme Q10 for weight loss

Many overweight people have very low levels of Coenzyme Q10, and supplementation allows them to lose weight . This is because the role of coenzyme Q10 can accelerate fat metabolism.

10) Coenzyme Q10 and periodontal disease treatment

Coenzyme Q10 has also been successfully used in the fight against periodontal disease , especially gingivitis (gingival disease). Deficiency of Coenzyme Q10 leaves tissues affected by gingivitis. And experiments have shown that a small 50mg / day supplement can reduce inflammation. More recent studies have shown that topical application of coenzyme Q10 dissolved in soy sauce (oily food) to the affected area (periodontal sac) can reduce bleeding and sac depth.

The total content of coenzyme Q10 in the human body is only 500-1500mg, and it decreases with age. Coenzyme Q10 levels in human organs peak at the age of 20 and then decrease rapidly. The reduction in Coenzyme Q10 concentration is particularly pronounced in the heart. 77-year-olds reduced coenzyme Q10 in the heart muscle by 57% compared to 20-year-olds.

Some experts engaged in research with coenzyme Q10 believe that many people, especially the elderly and those engaged in intense exercise, will lack coenzyme Q10 and can benefit from supplementation, indicating that coenzyme Q10 is the only fat-soluble antioxidant synthesized in the body in Excellent effects on aging, anti-fatigue, maintaining youth and vitality of the body. The recommended daily dose for health maintenance is 30 mg, which is quite high in the treatment of various diseases. Daily doses of up to 300 mg have been reported, and benefits have been found for supplementation. Coenzyme Q10 should be taken with a fat-containing diet, or even preferably in combination with soybean oil or vegetable oil, which can increase its complete substantial absorption. The human body can quickly absorb the supplement of coenzyme Q10.

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Import label: Amex Coenzyme Q10 Soft Capsules

[Ingredients ] Coenzyme Q10 30 mg

[Accessories ] Edible gelatin, glycerin, purified water

[Suitable crowd] adult

[Eating method] Adults, 1 capsule 3 times a day, preferably with meals

[Storage method] Sealed in a cool and dry place, away from children

[Shelf life ] three years

[Country of origin ] United States