What Is the Relationship Between Corticosteroids and Depression?

GR is a member of the conservative nuclear receptor superfamily and belongs to nuclear transcription factors. Its family members mainly include mineralocorticoid receptors, androgen receptors, thyroid hormone receptors, vitamin D receptors and other receptors. After being activated, it binds to a specific DNA sequence on the target gene in the nucleus to regulate gene transcription and exert various biological effects.