What is osteoclast?
Osteoclasts are large cells with more than one core. In general, they will contain 5 to 20 cores, but may have up to 200. They are found in bones that are slightly larger than osteoclast itself. Scientists believe that osteoclasts actively create these holes known as "Howwship's lacunae".
On the side of osteoclast, which is next to the bone, there are a number of microvilli that enter the bone. This border represents an active cell surface where it can break bones. Osteoclasts produce several enzymes that allow them to resorb the bones, but the primary is acid phosphatase.
enzymes produced by osteoclasts are able to remove inorganic calcium and phosphorus from bone tissue. They can also break organic materials such as collagen, which forms the bone itself. Initially, the bone is distributed apart with minerals still inside the tissue.
When osteoclast spends bone tissue, the toeals are above the notch in the bone. This creates an area known as the resorptive pit under the whole. Some enzymesThey are released into the pit and dissolve the bone into pieces. Osteoclast occupies pieces of bone and dissolves them.
During this process, calcium and phosphorus minerals are brought to osteoclast in special closed compartments called Vesicula. The vesicles pass through the cell and are released into the bloodstream. This process can be used to increase the levels of minerals in the body because calcium and phosphorus are used for many processes. Osteoclasts will not resorb the bones that do not contain minerals, because this bone is generally still in a state of development.
osteoblasts and osteoclasts are made of different cellular processes. Some proteins, such as a factor stimulating colony of macrophages (MCSF) sent to distinguish the cells into osteoclasts. However, osteoblasts create these proteins, so their presence is necessary for the development of osteoclasts. Deficiencies in genes coding MCSF and other proteins can leadto the lack of osteoclasts. It can also lead to the development of osteopetrosis, which is a rare condition when bones are heavier.