What is cholesterol biosynthesis?
The
process in the body to form cholesterol is called cholesterol biosynthesis. It consists of a number of steps that rely on many enzymes and processes to achieve the final product. Cholesterol is essential for normal body functioning in the right amount. It is used for the production of cell walls and hormones, among other functions. However, too much cholesterol can cause atherosclerosis or narrowing blood vessels and result in heart disease, heart attack or stroke. These are metabolized in the body to a product called Acetyl Coa, which is then further metabolised through a series of phases of enzymes acetoacetyl Thiolas, HMG coa synthase and HMG coa reductase to the product melonate. At this point in the biosynthesis of cholesterol statins, one of the most used drugs for high cholesterol, Act. It then undergoes another metabolism on the glass or coenzyme Q10 or Ubiquinon. COENZYME Q10 is an antioxidant.
Squalen isconverted by glass epoxidase and oxidosqualen by cyanic into lanosterol. Lanosterol passes through various other processes that result in the final cholesterol product. It is a highly simplified explanation of cholesterol biosynthesis, and each step may include a number of processes, each of which requires specific enzymes. This again emphasizes the complexity of body systems.
As mentioned earlier, too much cholesterol is not good and it is necessary to treat with high cholesterol levels, first changes in the lifestyle of such AS diet and exercise, and then, if necessary, medication treatment. The best known class of medicines used to treat high cholesterol are HMG COA inhibitors of reductase or statins. These include atorvastatin, orthopic and rosuvastatin, which are available according to various trade names in different countries, usually only according to the regulation.
statins work by inhibiting the effect of enzyme, HMG Co Reductase that is part of cholesterol biosynthesis in the step that producesMevalonát. Inhibition of the enzyme is reduced to mevalonate and therefore cholesterol is reduced. As with any drugs, statins can interact with other medicines, contraindicate in certain conditions and cause adverse side effects in some people. They should only be used under the supervision of a doctor.