What are indoleamins?
indoleamins are organic compounds composed of Indol groups that have an amino group on them. Indoles are molecules containing nitrogen, which form part of many biologically active molecules. In the case of indoleamins, the structure of the essential amino acids of L-flytophan are part of the structure of essential amino acids. The metabolism of this compound is considered the first step in the biosynthesis of indoleamins.
Many indoleamins pronounced biological activity. A prototypical example is serotonin. This compound is a neurotransmitter - chemicals used by the brain to transmit signals. Other indoleamins include melatonin, strong hormone and N, N-dimethyltryptamine, hallucinogen.
Serotonin is one of the highest indoleamins. It is found in animals, plants and mushrooms. It is consumed in a human diet in fruit and vegetables. In animals, most serotonin are found in the gastrointestinal tract. The rest is located in the center of the nervous system.
Many studies have been performed on serotonin for its effects on physioloGII man. It is believed that directly or indirectly affects most brain cells and has great effects on mood. Indoleamine hypothesis depression assumes that depression is the result of an imbalance in serotonin levels. To correct it, selective serotonin (SSRI) inhibitors (SSRI) have been developed. These compounds are widely used as antidepressants.
It is assumed that these drugs work because they prevent serotonin backward. The neurotransmitter remains active, so the increased serotonin has a greater effect. If the SSRI is removed, serotonin levels are reduced. This brings an increase in depression.
Serotonin is inactivated by enzyme monoamine oxidase, also known as Mao. MAO inhibitors (Maoi) are an older class of antidepressants. They can interact with compounds in the human diet. These inhibitors are used less frequently than SSRI. In young adults and childrenThere is some discussion of the use of SSRIS because there is an side effect of increased risk of suicide.
melatonin is another indoleamine and is synthesized from serotonin. This hormone is widespread throughout the body, especially in the skin, and helps to regulate the circadian rhythm. This is a way to keep the body over 24 hours of cycles. Melatonin is sometimes considered a supplement that helps regulate sleep/awakening cycles for people with jet delay disorders or circadian rhythmic disorders. Some countries do not allow the sale of melatonin as a supplement to people.
amino acid l-flightophane is metabolized by an enzyme indoleamine by a 2.3-diaxygenase. This enzyme is found in a series of tissues. Degrades L-flytophan to kynurenin compounds. These compounds have antimicrobial properties.
The Distribution Distribution product also contributes to suppressing immune responses. If it is excessively expressed, this can lead to a compromise of the immune system. Scientists are examining the use ofIndoleamine inhibitors of 2,3-diaxygenases to block this activity and provide a form of immunotherapy.