What are phospho antibodies?

Protein phosphorylation is the addition of a phosphate group (PO4) to a specific protein, usually on serine, threonin or tyrosine rest. In general, protein phosphorylation is one of the main ways in which the transduction of signal and enzymatic activity is regulated in the cells. Antibodies that detect these areas of phosphorylated proteins are called phospho antibodies. The ability to detect phosphorylated rest of the protein at a particular location is a valuable tool for detecting cellular signaling activity and is the key to understanding many cellular signaling processes. Of protein interaction with other proteins or molecules. Phosphorylation plays an important role in many important cellular signaling processes, including cellular growth and death, paths that do not Indurate or inhibit tumorigensy, hormonal signaling processes and energy production. Proteins are phoshoras by enzymes called kinases and defosphorylated enzymes called phosphatases. The process of reversible phosphorylation therefore allows the cells of uplato tie strict control over these important signaling paths.

antibodies are Y -shaped molecules that contain places bound to antigen at the end of each arm. Generally, antibodies recognize unique sequences in their corresponding antigens called epitopes. Naturally, the production of antibodies occurs as part of the immune response when the host is exposed to a foreign body, allowing the antibody to specifically recognize and neutralize these foreign antigens. This natural process can be used for research purposes by generating antibodies that specifically detect interest in antigen or protein. When generating research antibodies, host species are often rabbits, mice, sheep or goats, but scientists can also use immune cells in culture to create antibodies against antigen interest.

Fosfo antibodies can be used in research or clinical applications. In clinicalThe environment can detect a particular phosphorylated phospho protein with an antibody sample in the tumor sample to help assess the degree of tumor or even help predict the outcome of the disease. In research settings, phospho antibodies are often used to study cell signaling paths in response to a specific stimulus.

Many antibodies are available to provide phospho antibodies to scientists and clinical doctors. Scientists can choose these antibodies from the antibody catalog, which often contains reagents for hundreds of different phosphorylated proteins. In addition, several antibodies suppliers offer the production of their own antibodies for rarely studied phosphorylated proteins for which the Commercial PhosphoS antibody is not available.