What Is a Genome Database?

The Genome Database (GDB) saves and processes genomic atlas data for the Human Genome Project (HGP). GDB's goal is to build an encyclopedia about the human genome. In addition to constructing a genomic map, it has also developed methods for describing sequence-level genomic content, including sequence variations and other descriptions of function and phenotype.

Genomic database

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The Genome Database (GDB) saves and processes genomic atlas data for the Human Genome Project (HGP). GDB's goal is to build an encyclopedia about the human genome. In addition to constructing a genomic map, it has also developed methods for describing sequence-level genomic content, including sequence variations and other descriptions of function and phenotype.

Chinese name

Genomic database

Belong to

Genome database is

GDB, established by Johns Hopkins University in the United States in 1990, is an important human genome database and is managed by the Bioinformatics Center of the Children's Hospital of Canada.

The GDB database provides genomic structure data in tabular form, including genetic units, PCR sites, cell genetic markers, ESTs, contigs, repeats, etc .; and can display genomic maps including cytogenetic maps, linkage maps , Radiation hybrid map, contig map, transcript map, etc .; and give a database of allelic polymorphisms. In addition, the GDB database also includes hypertext links to other network information resources such as the nucleic acid sequence database GenBank and EMBL, the genetic disease database OMIM, and the literature abstract database MedLine.

The GDB database is developed with large commercial software Sybase database management system, and the gene map display program is written in Java language, which provides a good interface for users. The disadvantage is that the transmission speed is limited.

The GDB database is the fruit of international cooperation, and its purpose is to provide human genome information resources for biologists and medical personnel engaged in genomic research. The data comes from the results of genomic research in various countries around the world. Registered users can directly add and edit data to the GDB database.

AceDB is the genome database of Caenorhabditis elegans. It should be noted that AceDB is both a database and a

Yeast genome database SGD (Cherry et al., 1998) is a beer yeast genome database resource that has completed the complete sequencing of the genome, including a large amount of information on molecular biology and genetics of beer yeast. Through the Internet, you can access the entire genome information resource of the database, including genes and their products, the phenotypes of some mutants, and various related annotation information. The yeast genome was the first eukaryotic genome to be completed in 1998, and its importance is self-evident. SGD integrates various functions. Biologists can perform sequence homology search through this database, analyze gene sequences, register yeast gene names, view various maps of the genome, display the three-dimensional structure of protein molecules, and design Primer sequences that effectively clone yeast genes. The database provides users with physical maps, genetic maps, and sequence characteristic maps of the yeast genome through a convenient and practical graphical interface.

The TDB database of the American Genomics Institute TIGR includes DNA and protein sequences, gene expression, cell functions, and protein family information, and it contains classified information of people, plants, and microorganisms. It is a large-scale comprehensive database. In addition, the database also includes a model organism genomic information database, which contains TIGR microbial genome information from all over the world, including Lyme Pathogenic B. Burgdorferi, H. Influenzae, and H. Pylori ), M. genitalium, etc., and the parasite database (T. brucei P. falciparum), human, mouse, rice, Arabidopsis (A. Thaliana) and other genomic information resources, some of which can be derived from TIGR Download from FTP site.

The GenBank nucleic acid sequence database covers sequence data and partial annotation information from the complete genome to a single gene, which is called a primary database. In addition, there are some more targeted genomic resources, or specialized databases. These dedicated databases include both the data from the above-mentioned primary databases and information or cross-links obtained from other database resources. This specialized database is mainly divided into two categories, one is the model organism genome database, and the other is related to special sequencing technology. Although these databases also contain sequence data, their characteristics are mainly to provide a complete data resource for a specific model organism, such as yeast (Saccharomyces cerevisiae), nematodes (Caenorhabditis elegans), fruit flies (Drosophila melanogaster), pseudo-flies Arabidopsis thaliana, Helicobacter pylori, etc. These databases collect relevant information from different levels in order to have a more complete understanding of the entire genome of a model organism.