What Is Metabolic Engineering?

Metabolic engineering refers to the use of multi-gene recombination technology to purposefully modify and transform the metabolic pathways of cells, change the characteristics of cells, and combine with cellular gene regulation, metabolic regulation and biochemical engineering to build new metabolic pathways. A new subject area developed for the production of specific purpose products. It can be said to be the advanced stage of genetic engineering.

Metabolic engineering

In order to meet the specific needs of human beings, the metabolic pathways of microorganisms have been operated for nearly half a century. in

Metabolic engineering is an emerging discipline that uses genetic engineering techniques to transform the metabolism of cells to improve their performance. In 2003, J. Keasling, University of Berkeley, used yeast cells to express natural phytopharmaceutical molecules to achieve engineering microbial metabolism and engineering pharmacy. Using the principles of systems biology, transgenic biotechnology and computer software-aided design technology, the secondary metabolic response chain in the cell is redesigned, and genes and gene regulatory networks are artificially synthesized, thus entering the synthetic biology of genetic engineering and genetic engineering-system biology Genetic engineering era.

Recent developments show that it has important applications in plant and animal metabolic engineering and gene therapy and metabolic analysis to human tissue cells. The novelty in this field lies in the integration of molecular biotechnology and mathematical analysis tools, which helps clarify the metabolic flux control of genetic modification and the reasonable selection of targets. By providing an accurate and rigorous description of cell biology, metabolic engineering can also greatly advance the development of functional genomics.

The main goal of metabolic engineering is to identify specific genetic operations and control of environmental conditions to enhance the yield and productivity of biotechnological processes, or to modify the properties of cells in general. The main content of this book includes pathway integration and the importance of considering metabolic flux as a basic determinant of cell physiology. Metabolic engineering minimizes the complexity of mathematics and provides some necessary supplementary instructions as background material for different mathematical operations.