What Is a Pleomorphic Sarcoma?
Polymorphic lipomas are rare and occur in men over middle age.
Basic Information
- English name
- pleomorphic lipoma
- Visiting department
- Dermatology, Oncology
- Multiple groups
- Middle-aged men
- Contagious
- no
Clinical manifestations of pleomorphic lipoma
- It is clinically similar to spindle cell lipoma, and it occurs more frequently in shoulders and necks, with a diameter of 1 to 13 cm. It grows slowly and a few recent growths have accelerated. Although both pleomorphic lipoma and spindle cell lipoma show aberrations of nuclear chromosome 16q, the disease is still benign.
Pleomorphic lipoma examination
- Histopathology: The state of tumor tissue is clear. Tumor cells have a high degree of pleomorphism. Although mature adipocytes are seen, most adipocytes are of different sizes. Adipocytes or vacuolated cells are seen in about half of the tumors. Among the stroma, there are a large number of dense, staggered collagen bundles. Tumor cells can have multiple overlapping nuclei, or arranged in petal-shaped giant cells. Intranuclear chromosome division is rare, without necrotic tissue.
Diagnosis of pleomorphic lipoma
- According to clinical manifestations, skin lesion characteristics, and histopathological characteristics can be diagnosed.
Differential diagnosis of pleomorphic lipoma
- Liposarcoma
- Infiltrative growth, more tumor cells, more atypical nucleus, and atypical mitotic figures, many vacuolated adipocytes, no thickened collagen fiber bundles, rare petal-shaped giant cells.
- 2. spindle cell lipoma
- Spindle cells account for most of them, and they are small focal in pleomorphic lipomas.