What Is High Grade Dysplasia?

Atypical hyperplasia is also called dysplasia. Mainly refers to the abnormal proliferation of epithelial cells, which are characterized by different cell sizes, diverse shapes, disordered arrangements, and extreme loss. Large nuclear staining, increased cytoplasmic ratio, irregular karyotype, and increased mitotic images (generally no pathological mitotic images). The cells have a certain degree of atypia, but not enough to diagnose cancer. According to the severity of the disease, it can be divided into mild, moderate and severe. For example, dysplasia of squamous epithelium of the cervix can be divided into: mild heterogeneous epithelial cells involved in the lower layer of the epithelium 1/3 (grade ), moderate involvement of the epithelium 2/3 in the whole layer (grade ), affected More than two thirds of the whole epithelium is severe (III). In recent years, the concept of intraepithelial neoplasia (IN) has been generally accepted. That is, grades I, II, and III atypical hyperplasia are called IN-I, II, and III, respectively, of which IN- include carcinoma in situ. Such as cervical intraepithelial neoplasia (CIN), vulvar intraepithelial neoplasia (VIN) and so on.

Atypical hyperplasia

Atypical hyperplasia is also called dysplasia. Mainly refers to the abnormal proliferation of epithelial cells, which are characterized by different cell sizes, diverse shapes, disordered arrangements, and extreme loss. Large nuclear staining, increased cytoplasmic ratio, irregular karyotype, and increased mitotic images (generally no pathological mitotic images). The cells have a certain degree of atypia, but not enough to diagnose cancer. According to the severity of the disease, it can be divided into mild, moderate and severe. For example, dysplasia of squamous epithelium of the cervix can be divided into: mild heterogeneous epithelial cells involved in the lower layer of the epithelium 1/3 (grade ), moderate involvement of the epithelium 2/3 in the whole layer (grade ), affected More than two thirds of the whole epithelium is severe (III). In recent years, the concept of intraepithelial neoplasia (IN) has been generally accepted. That is, grades I, II, and III atypical hyperplasia are called IN-I, II, and III, respectively, of which IN- include carcinoma in situ. Such as cervical intraepithelial neoplasia (CIN), vulvar intraepithelial neoplasia (VIN) and so on.

Atypical hyperplasia is the morphological manifestation of precancerous lesions. Common atypical hyperplasia in clinicopathological work are: squamous epithelium atypical hyperplasia, which is more common in the esophagus, cervix and oral cavity, leukoplakia of the vulva, and chronic skin ulcers; atypical hyperplasia of glandular epithelium (dysplasia), more common in the stomach , Gallbladder, liver cells, endometrium, mammary duct epithelium, etc. The timely detection and treatment of these atypical hyperplasias can prevent the occurrence of cancer at the corresponding site. However, it must be pointed out that not all precancerous lesions are necessarily transformed into cancer, and not all cancers have a clear stage of precancerous lesions.