What is Levodopa?

Levodopa tablets are used for Parkinson's disease and Parkinson's syndrome.

Drug Name: Levodopa tablets

Drug type: Prescription drugs, medicines for medical workers' injuries
Use classification: Antiparkinsonian

Levodopa tablets ingredients

The main ingredients of this product are: Levodopa Chemical name: (-)-3- (3,4-dihydroxyphenyl) -L-alanine Chemical structural formula:

Molecular formula: C ₉ H ₁₁ N0 ₄
Molecular weight: 197.19

Levodopa sheet traits

This product is white or off-white film.

Levodopa tablets indication

For Parkinson's disease and Parkinson's syndrome.

L-Dopa Tablet Specifications

0.25g

Levodopa tablets dosage

Take 0.25 g (1 tablet) once orally, 2-4 times a day, and take after meals. In the future, depending on the patient's tolerance, increase the dose every 3 to 7 days, and the increase range is 0.125-0.75 g (1/2 to 3 tablets) per day until the optimal effect. The maximum daily amount is 6 g (24 tablets), divided into 4-6 times. After encephalitis and elderly patients should reduce dosage.

Adverse reactions of levodopa tablets

Common adverse reactions are: nausea, vomiting, orthostatic hypotension, abnormal involuntary movements of the head, face, tongue, upper limbs and upper body, depression, and difficulty urinating. Less common adverse reactions are: hypertension, arrhythmia, and hemolytic anemia. There have been reports of patients with pathological gambling, increased libido, and hypersexuality after using dopamine receptor agonist drugs for the treatment of Parkinson's disease in foreign countries. Especially at high doses, it is generally reversible after reducing the therapeutic dose or stopping the drug.

Contraindications to levodopa tablets

Severe mental illness, severe arrhythmia, heart failure, glaucoma, peptic ulcer, and those with a history of convulsions are contraindicated.

Precautions for levodopa tablets

Hypertension, arrhythmia, diabetes, bronchial asthma, emphysema, liver and kidney dysfunction, and urine retention should be used with caution. Elderly people with osteoporosis, who are effectively treated with this product, should slowly resume normal activities to reduce the risk of causing fractures. Pay attention to check blood routine, liver and kidney function and electrocardiogram during medication.

Levodopa tablets for pregnant and lactating women

This product can secrete human milk and also reduce milk secretion; animal experiments show that this product can cause visceral and skeletal deformities. Pregnant and lactating women should be disabled.

Levodopa tablets for children

Use with caution.

Levodopa tablets for elderly

still uncertain

Levodopa drug interactions

1. Combining this product with non-selective monoamine oxidase inhibitors can cause acute adrenal crisis.
2. Combining this product with papaverine or vitamin B ₆ can reduce the efficacy of this product.
3. The combination of this product with acetylspiramycin can significantly reduce the blood concentration of this product and weaken its efficacy.
4. The combination of this product with reserpine can inhibit the effect of this product and should be avoided.
5. This product is used in combination with antipsychotic drugs, because the two are antagonistic to each other, they should be avoided.
6. Combining this product with methyldopa can increase the adverse reactions of this product and enhance the antihypertensive effect of methyldopa.

Levodopa tablets overdose

Symptoms of poisoning: overdose can significantly aggravate the above-mentioned adverse reactions and can cause severe arrhythmia.
Treatment: immediately induce vomiting, gastric lavage, take measures to increase excretion, and carry out corresponding symptomatic treatment and supportive therapy according to the condition.

Pharmacology and Toxicology of Levodopa Tablets

This product is a dopamine-like anti-Parkinson's disease drug. L-dopa is a precursor substance for the synthesis of dopamine in the body. It has no pharmacological activity. It enters the human center through the blood-brain barrier. Role in improving symptoms of Parkinson's disease. As this product can increase neurotransmitters such as dopamine and norepinephrine in the brain, it can also increase the brain's tolerance to ammonia, and is used to treat liver coma, improve central function, make patients awake, and improve symptoms.

Pharmacokinetics of Levodopa Tablets

It is absorbed by the small intestine after oral administration. After fasting, the blood concentration reaches 1-2 hours, and it is widely distributed in various tissues in the body. 1% enters the center to convert to dopamine and play a role. Most of the rest are decarboxylated into dopamine in the brain, so the effect is slow. The half-life (t _1/2 ) is 1 to 3 hours. If a peripheral dopa decarboxylase inhibitor is used, the amount of levodopa can be reduced to increase the amount of levodopa into the brain, and the adverse reactions caused by peripheral dopamine can be reduced. 80% after oral administration, it degrades into dopamine metabolites within 24 hours, mainly homovanillic acid and glyoxylic acid, which are excreted by the kidneys, and some metabolites can make urine red. The prototype is excreted in about 5% of the body and can be secreted through milk.

Levodopa tablets storage

Shaded and sealed.

Levodopa tablets packaging

Plastic bottle: 100 tablets / bottle

Validity of levodopa tablets

36 months

Levodopa tablets

"Chinese Pharmacopoeia" 2010 edition two ^[1]