How Effective Is Docetaxel for Breast Cancer?

Texotetidol paclitaxel injection is a medicine, the dosage is: the recommended dosage is 75 mg / m2 every 3 weeks, and intravenous infusion for 1 hr.

Texotetidol Taxol Injection

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Texotetidol paclitaxel injection is a medicine, the dosage is: the recommended dosage is 75 mg / m2 every 3 weeks, and intravenous infusion for 1 hr.

Chinese name

Texotetidol Taxol Injection

Adverse reactions

: Myelosuppression, etc.

Results

Formation of stable non-functional microtubule bundles

Mechanism

Strengthen tubulin polymerization

Product name: Docetaxel injection

The mechanism of action of this product is to strengthen tubulin polymerization and inhibit microtubule depolymerization, leading to the formation of stable non-functional microtubule bundles, thereby destroying mitosis of tumor cells. The concentration of this product in the cell is 3 times higher than that of paclitaxel, and the residence time in the cell is longer, which is an important reason for the greater antitumor activity of this product than paclitaxel in in vitro tests. In vivo, it is effective against colon cancer, breast cancer, lung cancer, ovarian tumor grafts, etc. in mice. This product does not produce cross-resistance to cisplatin, etoposide, 5Fu, or paclitaxel-resistant cell lines.

: Intravenous injection of this product at a dose of 100mg / m2 for about 1 to 2 hours. The average volume of the body is 113L, t1 / 2 is 4min, t1 / 2 is 36min, and t1 / 2 is about 11.2h. The clearance rate in vivo is about 20L / h.m2, with high protein binding rate and low renal excretion rate. Metabolized in the liver, mainly excreted from the feces through the biliary tract, and excreted by the urine only accounts for 5% to 7% of the given dose; patients with abnormal liver function reduce the clearance rate of this product in vivo, but the age difference is significant No significant change in kinematics.

: Myelosuppression. Allergic reactions. Fluid retention. Gastrointestinal reactions such as nausea, vomiting or diarrhea may occur. Hair loss. Fatigue. Mucositis. Joint pain and muscle pain. Hypotension. Neurotoxicity and cardiovascular side effects rarely occur.

Interaction: This product is combined with cisplatin or vinorelbine or doxorubicin, suggesting beneficial results. When used in combination with ketoconazole, adverse interactions may occur. Use caution when using it.

: Recommended dose is 75 mg / m2 every 3 weeks, intravenous infusion for 1 hr.

: Patients with white blood cell count less than 1500 / m3 are disabled. Disabled during pregnancy and lactation. Pre-treatment with glucocorticoids, such as dexamethasone, is required to reduce fluid retention. The number of blood cells should be monitored frequently during treatment.

Texotetidol paclitaxel injection ^[1]