What are the differences between Simvastatin and Pravastatin?

There are not many differences between simvastatin and orthopica, as both belong to the same class of cholesterol reducing drugs and cause the same mechanism of action. However, their pharmacokinetics, the potential for interaction with other medicines and normal dosage, are slightly different. Both Simvastatin and Pravastatin are usually only available under the regulation and can be available as different trade names in different countries according to the manufacturer. Inhibition of HMG COA reductase, enzyme involved in cholesterol synthesis in the body, decreases cholesterol levels. High cholesterol or hypercholesterolemia, a very common problem around the world, can cause blood vessels blocking and increase the risk of serious conditions such as stroke, heart attack and kidney disease. While lifestyle changes can be recommended for the first time, such as dietary change and Expro reduction of cholesterol levels is often required. The half -life of the drug concerns how long it has remained at a certain level in the body, so the shorter the half -life, the shorter the time of the action. MostIn cases, statins are considered to be a daily dose.

Simvastatin and Pravastatin differ in the force that is usually used. Simvastatin is usually given at a dose of 10 mg at night initially and can be slowly increased, usually at four -week intervals, up to a maximum of 80 mg daily, depending on tolerance and reaction. Pravastatin is also usually launched 10 mg daily and is processed, similarly at four -week intervals, but to a maximum of 40 mg.

As with any drugs, Both drugs can interact with other medicines, including homeopathic, over -the -counter and complementary medicines. These should be discussed with a prescription physician before starting treatment by some medicine. Pravastatin tends to be slightly less susceptible to interactions due to the fact that it is not metabolized by the cytochrome P450 system, which is a system that can often cause interactions due to inhibition or inductionSystem by other medicines.

Adverse reactions may occur both on simvastatin and orthopper and generally related to both. Some side effects that have been reported include gastrointestinal side effects, muscle effects and liver toxicity. The physician will carefully monitor patients on statins in terms of any signs of serious adverse effects, and if they should be experienced, the patient should contact his doctor immediately.