What Is Alprazolam?

Alprazolam tablets, the indications are mainly used for anxiety, tension, agitation, can also be used as a supplementary drug for hypnosis or anxiety, can also be used as an anti-panic drug, and can relieve the symptoms of acute alcohol withdrawal. It should be used with caution in patients with mental depression.

Drug Name: Alprazolam
Drug type: Prescription medicines, essential medicines, medicines for medical workers' injuries

Special medicine: Psychotropic drugs
Use classification: Benzodiazepines

Alprazolam tablets ingredients

The main ingredients of this product are: alprazolam.
Chemical name: 1-methyl-6-phenyl-8-chloro-1-H- [1,2,4-triazole [4,3-] [1,4]] benzodiazepine Structural formula:

Molecular formula: C ₁₇ H ₁₃ ClN ₄
Molecular weight: 308.77

Alprazolam tablets

This product is a white tablet.

Alprazolam tablets indications

It is mainly used for anxiety, tension and agitation. It can also be used as a supplementary drug for hypnosis or anxiety. It can also be used as an anti-panic drug and can relieve the symptoms of acute alcohol withdrawal. It should be used with caution in patients with mental depression.

Alprazolam tablets specifications

0.4mg

Alprazolam tablets dosage

Usual dose for adults: Anxiolytic, start with 0.4mg (1 tablet) at a time. 3 times a day, the dosage will increase as needed. The maximum limit can reach 4mg (10 tablets) per day. Sedative and hypnotic: 0.4-0.8mg (1-2 tablets), taken before bedtime. Anti-panic 0.4mg (1 tablet), 3 times a day, the dosage is increased as needed, the maximum daily amount can reach 10mg (25 tablets). The dosage for children under 18 years has not been determined.

Alprazolam adverse reactions

1. Common adverse reactions, drowsiness, dizziness, fatigue, etc. Occasional ataxia, tremor, urinary retention, and jaundice are occasionally seen in large doses.
2. Rare rashes, light sensitivity, and leukopenia.
3 Individual patients experience excitement, multilingualism, sleep disturbances, and even hallucinations. After stopping the medicine, the above symptoms quickly disappeared.
4 It is addictive. After long-term application, withdrawal symptoms may occur, which may be expressed as excitement or depression.
5. A few patients have dry mouth, lack of concentration, sweating, palpitations, constipation or diarrhea, blurred vision, and hypotension.

Alprazolam tablets contraindications

Use with caution:
1. Acute alcoholism in the central nervous system in a suppressed state.
2. Impaired liver and kidney function.
3 Myasthenia gravis.
4 Acute or prone to angle-closure glaucoma.
5. Severe chronic obstructive pulmonary disease.
6. Pilots, aerial operators, dangerous fine operators.

Alprazolam tablets precautions

1. People who are allergic to benzodiazepines may be allergic to this medicine.
2. Impaired liver and kidney function can extend the elimination half-life of this drug.
3 Sudden withdrawal of medication in patients with epilepsy can cause seizures.
4 Severe mental depression can aggravate the condition and even cause suicidal tendency. Preventive measures should be taken.
5. Avoid long-term addiction and addiction. If long-term use is not necessary, the drug should not be stopped suddenly, and it should be gradually reduced.
6. The presence of respiratory depression or hypotension often indicates overdose.
7. Patients with a low tolerance for this class of drugs should have a small initial dose and gradually increase the dose.
8. Use with caution when working at heights, pilots, fine work, and dangerous work.

Alprazolam tablets for pregnant and lactating women

1. In the third trimester of pregnancy, this drug increases the risk of teratogenicity in the fetus.
2. Long-term use of pregnant women can cause dependence, causing the newborn to show withdrawal symptoms. Medications in late pregnancy affect the central nervous activity of newborns. Medications before and during delivery can cause weak neonatal muscle tone. Pregnant women should avoid using them.
3 This medicine can be secreted into milk and should be used with caution in lactating women.

Alprazolam tablets for children

For children under 18 years of age, the amount has not been specified.

Alprazolam tablets for elderly

This medicine is more sensitive to the elderly, starting with a small dose, 0.2mg (half tablet) once, 3 times a day, gradually increasing to the maximum tolerated amount.

Alprazolam tablets drug interactions

1. Combined with central inhibitory drugs can increase respiratory depression.
2. The risk of addiction increases when combined with addictive and other potentially addictive drugs.
3 When combined with alcohol and general anesthetics, clonidine, analgesics, phenothiazines, monoamine oxidase A inhibitors and tricyclic antidepressants, they can enhance each other and the dosage should be adjusted.
4 Combined with antihypertensive drugs and diuretic and antihypertensive drugs, the antihypertensive effect can be enhanced.
5. The combination of cimetidine and propranolol reduces the clearance and prolongs the plasma half-life.
6. Due to the slowdown in the metabolism of the latter, the dosage of primidone needs to be adjusted.
7. When combined with levodopa, it can reduce the efficacy of the latter.
8. Used in combination with rifampicin to increase elimination of this product and reduce blood concentration.
9. Isoniazid inhibits the elimination of this product and causes an increase in blood drug concentration.
10 Combined with digoxin, it can increase the blood concentration of digoxin and cause poisoning.

Alprazolam tablets overdose

Sustained insanity, severe drowsiness, jitters, slurred speech, faltering, abnormally slow heartbeat, shortness of breath or difficulty, severe weakness. Overdose or poisoning should be treated symptomatically as early as possible, including vomiting or gastric lavage and supportive therapy in the respiratory cycle. Bariato should not be used when poisoning is abnormal. Flumazenil, a benzodiazepine receptor antagonist, can be used for the rescue and diagnosis of such drug overdose.

Alprazolam tablets pharmacology and toxicology

This product is a benzodiazepine hypnotic sedative and anxiolytic. The drug acts on the benzodiazepine receptor (BZR) of the central nervous system, strengthens the binding of the central inhibitory neurotransmitter -aminobutyric acid (GABA) and the GABA receptor, promotes the opening of chlorine channels, and hyperpolarizes cells Enhances synaptic inhibition mediated by GABAergic neurons and reduces neuronal excitability. BZR receptors are divided into type I and type II. It is believed that type I receptor excitement can explain the anxiolytic effects of BZ drugs, and type II receptors are related to the sedative and skeletal muscle relaxation effects of these drugs. Can cause inhibition of different parts of the central nervous system. With the increase of dosage, clinical manifestations can range from mild sedation to hypnosis and even coma. Can pass through the placenta and can be secreted into milk. Addictive, a few patients can cause allergies.

Alprazolam tablets pharmacokinetics

Oral absorption is fast and complete, and the plasma protein binding rate is about 80%. Peak blood concentration was reached 1 to 2 hours after oral administration. Plasma concentrations reached steady state in 2 to 3 days. T _{1/2 is} generally 12 to 15 hours, and the elderly is 19 hours. Metabolized by the liver, the metabolite -hydroxyalprazolam has a certain pharmacological activity. Excreted by the kidneys. There is very little accumulation in the body and it clears quickly after stopping the medicine.

Alprazolam tablets storage

Shaded and sealed.

Alprazolam tablets packaging

Medical plastic bottles, 100 tablets / bottle; aluminum plastic blister board, 20 tablets / board / box.

Alprazolam tablet expiration date

36 months for medicinal plastic bottles; 36 months for aluminum-plastic blister plates.

Alprazolam Tablets

"Chinese Pharmacopoeia" 2010 edition two ^[1]