What is sirolimus?
Sirolimus is an immunosuppressive drug that is prescribed for someone who receives a donor organ in organ transplantation. This medicine is also known as rapamycin and is a derivative of a bacterial species called streptomyces hygroscosicapions . Sirolimus is most often used to prevent organs to prevent people who undergo kidney transplantation. It is often used preferably for other immunosuppressive drugs, because after long -term use it has a lower risk of kidney toxicity.
Immunosuppressants is a drug that suppresses the immune system. These drugs are prescribed for a person who receives a donor body to ensure that its immune system does not allow an attack that could destroy the organ. The immune system attacks the donor authorities due to differences in the cells from the donor organ compared to the recipient's cells.
Sirolimus works by preventing immune responses to cytokine called interleukin-2. Cytokines are molecules that act as chemical signals, providisng instructions to cell im cellsof a Unnitory System. Interleukin-2 is a vital cytokine that is essential to activate T and B lymphocytes that can contribute to immune responses destroying organs.
possible side effects of sirolimu include joint, stomach and back pain; upset stomach; diarrhea; constipation; vomiting; weight gain; swelling of the hands, legs, ankles or legs; Difficulty of falling asleep; fever; and rash. These symptoms are usually temporary, but may have a longer period of time. Anyone who experiences these symptoms should discuss them with their doctor. Serious symptoms include inexplicable bruising or bleeding, difficulty breathing, cough, frequent urination, visual impairment, unusually fast or slow rhythm of the heart and mood swings. Anyone who has one or more of these symptoms should talk to your doctor as soon as possible.
Because sirolimus suppresses the une immlysty, anyone who uses this medicine has an increased risk of infection and is more likely to see thatE suffers from serious symptoms of infection. Drugs can slow wound healing, increase blood cholesterol and increase blood pressure. In addition, the use of this drug increases the risk of lymphoma, skin cancer and some other types of cancer. Symptoms such as changes in pigmented skin spots or moles, swollen lymph nodes, inexplicable weight loss, fever and night sweating should be discussed with a doctor.
People taking this medicine should try to avoid contact with people who have infectious diseases, including colds and influenza, as this medicine causes increased susceptibility to infection. Vaccination should only be performed with the consent of the doctor. In particular, it should be avoided by live vaccination because they have the potential to cause serious infection. Finally, direct sunlight should prevent as much as possible and protection from the sun should we weigh outside due to increased risk of skin cancer.