What is the connection between statins and fibrates?
4 They work with different mechanisms of action and in different ways affect different types of cholesterol. The selection that the class uses will be made by a prescription physician according to specific tests that determine the lipid profile of each patient.
Statins and fibrates consist of a number of drugs in each class. According to the manufacturer, they are known under different trade names in different countries. In most countries, they are only available as prescription. The dosage varies between each medicine in each class and the prescribed dose should never be exceeded.
hypercholesterolemia or high cholesterol is a common clinical condition that can cause atherosclerosis or narrowing blood vessels. This may have serious consequences such as a heart attack or stroke. The initial treatment of high cholesterol includes lifestyle changes such as diet and exercise. If medical treatment is required, statins and fibrates may be considered.
While both statins and fibrates work to reduce cholesterol in the body, they work differently. CHolesterol is divided into lipids with high density (HDL), low density lipids (LDL) and triglycerides. LDL is placed in arteries and causes narrowing or clogging while HDL protects arteries. Triglycerides increase the risk of tempered arteries.
For this reason, elevated levels of LDL and/or triglycerides are problematic. Statins and fibrews act differently, with statins have a more defined effect on LDL, while fibrates can more affect triglycerides levels. The choice between them will be made clinically.
FIBRETES works mainly by stimulating lipoprotein lipases and liver lipases, enzymes that are responsible for breakdown triglycerides causing reduced triglycerides levels. They can also slightly increase HDL production and reduce LDL levels in the blood by reducing its production in the liver. Statins, on the other hand, reduce LDL inhibit HMG-Coa reductase, an enzyme involved in LDL production. Slightly also sniThey live triglycerides and can slightly increase HDL.
As with all drugs, statins and fibrates may have adverse side effects, interact with other medicines or be contraindicated in people with some clinical conditions. Any medicine, including complementary, homeopathic or over -the -counter medicines, should be discussed with a prescription doctor before starting any drug. Basic health conditions, allergies, pregnancy or pregnancy and lactation should also be discussed.