What is the connection between statins and grapefruit?
The connection between statins with boat cholesterol and grapefruit concerns how the body can metabolize these drugs. Specifically, grapefruit juice can reduce statin metabolism speed, causing too many cholesterol drugs in the body. In most cases, this occurs only if the quart (0.95 liters) or more grapefruit juice is consumed. Some people can experience adverse effects with only one daily glass of grapefruit juice or one of the whole grapefruit. It works by reducing the liver ability to produce low density lipoprotein (LDL) or "bad" cholesterol and slightly increases the production of high density lipoprotein (HDL) or "good" cholesterol. Statins immediately lower cholesterol levels. After about six weeks of treatment, long -term effects are present. This enzyme not only reduces the amount of absorbed statins, but also causes them to be absorbed more slowly. Grapefruits contain furanocoumarins that can i inrib the function of the enzyme. As a result, too many medicines will be metabolized too quickly.
People who want to continue drinking grapefruit juice should consider buying juice that has been removed during production Furanocoumarina, which can help avoid problems related to statins and grapefruit consumed. The solvents and absorption resins can be used to remove 99 percent of furanocoumarins. All other natural ingredients of grapefruit juice are preserved. Therefore, the taste and other health benefits will not change.
If too many statins remain in the bloodstream, serious side effects may occur. From TH can be serious muscle conditions such as myopathy or rabdomyolyozae toxicity. On the other hand, renal failure, liver failure or other life -threatening disorders can be triggered. The combination of statin and grapefruit can even cause death.
not all withTatins are affected. It is not known that grapefruit juice causes healing interactions with some drugs with a high cholesterol content because they use different enzymes than other medicines. Grapefruit has no effect on the enzyme used by these drugs. It is known that other drugs interact.
Regardless of the drug used for cholesterol, experts suggest that preventive measures will be taken. It is best to avoid all grapefruit juice, all grapefruit or grapefruit supplements if you are taking a medicine that uses the CYP3A4 enzyme. Other statins and grapefruit should not be consumed within hours. If serious side effects occur, immediate medical care should be sought to reduce the risk of long -term health problems.