What are chemokins?
Chemokins are a class of proteins that are an integral part of the process called cell trading in which migration cells are given chemical “instructions” where they should move in the body. Different different types of chemokines have specific roles in regulating the movement of different cell types, including cells involved in the development or maintenance of tissue and cells of the immune system. This process is an essential part of the body repair system and the immune system because it ensures that cells migrate to the right areas of the body when required.
The chemokin protein family was first discovered at the end of the 80s when the protein was previously known as Interleukin-8 reclassified as CXC Chemokin Ligand 8 or CXCL8. This reclassification occurred as a result of the discovery that the protein was able to activate the type of immune cell called neutrophil. Chemokins are sometimes called cytokines inductable pro -inflammatory activation. Previously, these prices had several other names, including Interkins, and Sig, Scy and Sis Family Cytokines.
The following research has found that chemokines act by means of a chemotaxis mechanism, allowing proteins to act as molecular signals to attract different types of cells to places where they are needed. The term chemotaxe describes the way in which the cells monitor the chemical gradient formed when the cells release chemokins into the tissues. For example, cells at the site of damage or infection release these proteins into the surrounding tissues. At the location itself, the concentration of chemokines is very high, but the concentration decreases due to the distance from the site. Thus, immune cells are able to find a place of damage or infection by monitoring a chemical gradient from low to high chemokin concentrations.
Chemokin proteins are generally small and tend to have a high level of sequence -art. This applies to the fact that there is a great similarity at the level of amino acid sequence in protein. Main differences in the amino acid sequence of meZI with different types of chemokins relate to the types of cells for which they are chemotactic. For example, some have an amino acid sequence called the ELR sequence. Those who have a sequence are mainly involved in chemotaxes for neutrophils, while those who have no sequence regulate the movement of several other types of immune cells, with the exception of neutrophils.
The primary role of chemokin proteins in the chemotaxic of the immune system suggests that they could be important therapeutic intervention goals for certain diseases. One such candidate is known as CCL5 or Rantes. This protein is involved in the regulation of an inflammatory immune response and can therefore be a suitable therapeutic aim in certain types of autoimmune and cancer, as well as disorders of the central nervous system, and even ISRDIAL disease. The central role of CCL5 also means that protein can serve as a diagnostic marker and as an indicator of forecast for these diseases.