What Is the Cytoskeleton?
The concept of cytoskeleton in the narrow sense refers to the system of protein fiber network (microtubule (MT) , microfilament (MF) and intermediate filament (IF)) in eukaryotic cells. The structural system it consists of is called the "cytoskeleton system", and the genetic system, biofilm system in the cell, and the "three major systems in the cell". It was not until after the 1960s that glutaraldehyde was fixed at room temperature, and the objective existence of the cytoskeleton was gradually realized. It is an important structure by which eukaryotic cells maintain their basic morphology. It is called the cytoskeleton, and it is usually considered as a kind of organelle in a broad sense. The broad concept of cytoskeleton is the network system formed by nuclear cytoskeleton, cytoplasmic skeleton, cell membrane skeleton and extracellular matrix. The nuclear skeleton, nuclear fiber layer, and intermediate fibers are structurally connected to each other and run through the nucleus and cytoplasm of the grid system. [1]
Cytoskeleton
- The narrow concept of cytoskeleton refers to
- Cytoskeleton
- The third fiber structure of the cytoskeleton
- For a long time, it has been thought that the cytoskeleton is only a structure unique to eukaryotes, but recent studies have found that it also exists in
- Cells often have abnormalities in the cytoskeleton system under pathological conditions. For example, in patients with Alzheimer's disease, a large number of twisted and deformed microtubules and a large number of damaged intermediate fibers are found in brain neurons; in malignantly transformed cells, they often show reduced and disaggregated microtubules, and abnormal cytoskeleton can be enhanced The ability of cancer cells to move. Studies have shown that the destruction of microfilaments and their focal adhesion spots and the appearance of actin bodies are related to the infiltration and metastasis characteristics of tumor cells. [3]
- Not only that, the cytoskeleton also contains a number of accessory proteins, such as:
- Cytoskeleton refers to the protein fiber network structure in eukaryotic cells. It was found late, mainly because the preparation of electron microscope samples was fixed at low temperature (0-4 ° C), and the cytoskeleton was depolymerized at low temperature. Until the 1960s,
- Cytoskeleton
- With glutaraldehyde fixed at room temperature, the objective existence of the cytoskeleton was gradually realized. The important structure by which eukaryotic cells maintain their basic morphology is known as the cytoskeleton, and it is often considered as a type of organelle in a broad sense. Cytoskeleton is not
- Cytoskeleton