What Is the Function of Coagulation?

Coagulation function refers to the ability of the blood to change from a flowing state to a non-flowable gel state. The essence is the function of soluble fibrinogen in plasma to change insoluble fibrin.

Coagulation

It can be divided into three basic steps: formation of prothrombinase complex (also known as prothrombin activation complex), prothrombin activation and fibrin production.

You can know whether the patient has abnormal blood coagulation function before surgery, and effectively prevent accidents such as bleeding during and after surgery, so as to obtain the best surgical effect.

The body's hemostatic function is accomplished by the combined action of platelets, the coagulation system, the fibrinolytic system, and the vascular endothelial system. In the past, we used bleeding time as a screening test for defects in hemostatic function, but because of its low standardization of operation, poor sensitivity, and failure to reflect the content and activity of coagulation factors, it has now been replaced by coagulation function tests. The coagulation function test mainly includes plasma prothrombin time (PT) and PT activity calculated from PT, international normalized ratio (INR), fibrinogen (FIB), activated partial thromboplastin time (APTT), and plasma thrombin Time (TT).

PT mainly reflects the function of the exogenous coagulation system. Prolonged PT is mainly seen in the reduction of congenital coagulation factors , , , and X, as well as the lack of fibrinogen and acquired coagulation factor deficiency (DIC, primary fibrinolysis, obstructive jaundice, vitamin K deficiency, and anticoagulants in the blood circulation. Increase, etc.); PT shortening is mainly seen in the increase of congenital factor V, early DIC, thrombotic diseases, oral contraceptives, etc .; monitoring PT can be used as a clinical monitoring of oral anticoagulant drugs.

APTT is the most reliable screening test for endogenous coagulation factor deficiency. The prolongation of APTT is mainly seen in hemophilia, DIC, liver disease, a large amount of imported blood, etc .; the shortening of APTT is mainly found in DIC, prethrombotic state, and thrombotic diseases; APTT can be used as a monitoring indicator for heparin treatment.

TT prolongation is seen in low or no fibrinogenemia and abnormal fibrinogenemia, increased FDP in blood (DIC), and the presence of heparin and heparinoids in blood (such as in the treatment of heparin, SLE, liver disease, etc.).

There was once an emergency patient who underwent preoperative laboratory tests with prolonged PT and APTT results. Suspected patients had DIC. Following the advice of the laboratory, the patient underwent a series of DIC tests and the results were positive. No obvious symptoms of DIC. If the patient does not undergo a coagulation test and the operation is performed directly, the consequences will be unimaginable. Many problems such as these can be discovered from the blood coagulation function test, and more time is found for clinical detection and treatment of diseases in a timely manner. A series of coagulation tests is an important laboratory test for coagulation function of patients. It can find abnormal coagulation function of patients before surgery and should be paid enough attention.