What is megakaryocyte?

Megakaryocyte is a large blood cell from bone marrow. Inside megacaryocytes, the main substance of the cell, known as the cytoplasm, breaks into small fragments to create what is called plates or thrombocytes. Plates are involved in blood clotting and repairing blood vessels and are located in the places of injury. Megakaryocytes are able to shape their cytoplasm for long protrusions that reach the gaps between the cells in the wall of the blood vessels. In this way, they release the plates into circulation. Megakaryocyte is the largest cell from bone marrow and has a giant size, at least ten times larger than the red blood cell. It has a core that has an irregular shape and contains much more DNA than the nuclei of normal cells. Golgi's complex is produced by proteins, some of which are later located inside plates in the form of plates. The granules of the plates are involved in the coagulation of blood. They are also used in a process where the plates are held on cells lining blood vessels to repair the gaps.

plates usually survive for about ten days, and each megakaryocyte usually produces about 4,000 platelets during its life. Normally there are approximately two -thirds of the plates in circulation, with the rest contained in the spleen. Plates are constantly produced to replace those that have died, and a healthy individual is maintained by a stable level in the blood. Sometimes there are diseases that affect megacaryoka, which have a subsequent effect on the production of plates.

In thrombocytopenia, the number of platelets is lower than normal, and this may arise from the problems of wijejich production, a decrease in the life of the pads or the relative reduction in the number of blood dilution. One of the causes is a defect of the process that releases megacaryocyte. The plates remain attached to the cytoplasm and less end in circulation. Symptoms of thrombocytopenia include excessive bleeding and red spots on the skin. Treatment will vary according to a specific cause.

primaryThrombocytosis is a disease where megacaryocytes are excessive production, with an abnormal increase in the number of platelets. The spleen can be enlarged and there may be other symptoms such as bleeding, especially in the intestine, and thrombosis or the formation of a clot, inside large blood vessels. If there are no complications, the disorder can be successfully treated with medicines that reduce the production of plates.