What Is an Inhibitory Postsynaptic Potential?

Inhibitory postsynaptic potential (IPSP) is the release of inhibitory transmitters (transmitters released by inhibitory intermediate neurons) from the presynaptic membrane, which leads to the increase in the permeability of the postsynaptic membrane to Cl. The current creates a local hyperpolarization potential. The post-synaptic membrane is hyperpolarized under the action of a transmitter, which reduces the excitation of the post-synaptic neuron. This potential change is called inhibitory post-synaptic potential (IPSP). The mechanism is that inhibitory transmitters act on the post-synaptic membrane, which opens the ligand-gated CI channel on the posterior membrane, causing CI inflow and hyperpolarization of the post-synaptic membrane.

Inhibitory post-synaptic potential

Inhibitory postsynaptic potential (IPSP) is the release of inhibitory transmitters (transmitters released by inhibitory intermediate neurons) from the presynaptic membrane, which leads to the increase in the permeability of the postsynaptic membrane to Cl. The current creates a local hyperpolarization potential. The post-synaptic membrane is hyperpolarized under the action of a transmitter, which reduces the excitation of the post-synaptic neuron. This potential change is called inhibitory post-synaptic potential (IPSP). The mechanism is that inhibitory transmitters act on the post-synaptic membrane, which opens the ligand-gated CI channel on the posterior membrane, causing CI inflow and hyperpolarization of the post-synaptic membrane.

Chinese name

Inhibitory post-synaptic potential

Foreign name

Inhibitory postsynaptic potential, IPSP

Features

Presynaptic membrane release of transmitters is triggered by Cl-influx

Mechanism

Postsynaptic membrane is hyperpolarized by a transmitter

(1) The release of transmitters from the presynaptic membrane is caused by Cl-inflow;

(2) Transmitters are in the form of vesicles

The post-synaptic membrane is hyperpolarized under the action of a transmitter, which reduces the excitation of the post-synaptic neuron. This potential change is called inhibitory post-synaptic potential (IPSP). Its mechanism is that inhibitory transmitters act on the post-synaptic membrane, which opens the ligand-gated CI ^- channel on the scutellum, causing CI ^- inflow, and the hyper-polarization of the post-synaptic membrane. In addition, the formation of IPSP may be related to the opening of K ⁺ channels or the closing of Na ⁺ and Ca ²⁺ channels in the postsynaptic membrane.