What is Coagulation?

Blood coagulation (blood coagulation), that is, blood coagulation, refers to the process of blood from a flowing liquid state to an immobile gel state, which is an important part of physiological hemostasis. The essence of blood coagulation is the process in which soluble fibrinogen in plasma becomes insoluble fibrin.

Clotting

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Blood Coagulation, that is:

The basic process of coagulation is a limited hydrolysis of a series of proteins , which can be roughly divided into three stages:

Under the action of thrombin, fibrinogen dissolved in plasma is transformed into fibrin monomers; at the same time, thrombin activates XIII to XIIIa, which connects fibrin monomers to each other to form a water-insoluble fibrin polymer, and Intertwined with each other, the blood cells are trapped inside, forming a blood clot, and completing the blood clotting process.

Blood coagulation is a series of enzymatic biochemical reaction processes. There are positive feedback effects in many places. Once started, it will continue quickly to ensure that the hemostatic effect of coagulation occurs in a short time.