What Is Glomerulosclerosis?
Glomerulosclerosis is a pathomorphological feature of glomerular disease. The lesion is characterized by sclerotic changes in the glomerular capillaries. Glomerulosclerosis is a late manifestation of the progression of various kidney diseases.
- English name
- glomerulosclerosis
- Visiting department
- Nephrology
- Common locations
- kidney
- Common symptoms
- Proteinuria, hematuria, hypertension
Basic Information
Causes of glomerulosclerosis
- Glomerular disease
- Various kidney diseases include hereditary nephritis, IgA nephropathy and non-IgA mesangial proliferative nephritis, and secondary kidney diseases such as diabetic nephropathy.
- 2. Renal tubule, interstitial and vascular diseases
- Reflux and obstructive nephropathy, acute and chronic interstitial nephritis, aristolochic acid nephropathy, systemic vasculitis, lupus nephritis, etc.
- 3. Other
- Polycystic kidney disease, uric acid nephropathy, hypertensive renal impairment, multiple myeloma renal impairment, etc.
Clinical manifestations of glomerulosclerosis
- The most common clinical symptoms are proteinuria and nephrotic syndrome. About two thirds of patients have a large amount of proteinuria and microscopic hematuria, and some have gross hematuria. Early with hypertension, nocturia and impaired renal function. Most of the conditions are gradually progressing, and infection, dehydration, and kidney damage drugs can aggravate the progress of the disease.
Glomerulosclerosis
- Urine routine
- Moderate or more (++) proteinuria, microscopic hematuria (polymorphism suggested by microscopic examination of urinary phase contrast), aseptic leukocyte urine, glucosuria. There may be abnormalities in renal tubular acidosis and urine concentration and dilution.
- Blood test
- Have hypoalbuminemia, plasma albumin below 30 g / l, hyperlipidemia. Serum IgG levels are reduced and complement is mostly normal.
- 3. Renal biopsy
- Pathology showed glomerulosclerosis atrophy. Unhardened pellets can be compensated.
Glomerulosclerosis diagnosis
- The diagnosis is confirmed based on the etiology, clinical manifestations and examination.
Glomerulosclerosis treatment
- General symptom
- Nutrition maintenance and support; lower blood pressure and lipids, lower urine protein.
- 2. Drugs
- Under the guidance of a doctor, use hormones and immunosuppressive drugs when necessary to protect the kidneys from toxins, prevent and delay renal damage, and slow the progress of the disease.
- 3. Other
- Avoid complications: including anticoagulation and antithrombotics; avoid infection; maintain water-electrolyte and acid-base balance; avoid and reduce adverse reactions to drug treatment. Dynamic review, timely medicine adjustment according to the condition.