What Is Hemoglobin Electrophoresis?
Hemoglobin (Hb) is a protein responsible for carrying oxygen in the human body and is also the main protein of human red blood cells. Hemoglobinopathy is a group of diseases caused by abnormal hemoglobin function due to structural abnormalities of globin peptide chains (, , , ) or changes in the rate of synthetic peptide chains. Common hemoglobin diseases include thalassemia, sickle cell anemia, methemoglobinemia, unstable hemoglobin disease, and the like. Diagnosis of the disease often relies on laboratory tests. Hemoglobin electrophoresis (HbEP) analysis is the most commonly used and most effective method, and it is an important method for the diagnosis of hemoglobin disease.
Basic Information
- Chinese name
- Hemoglobin electrophoresis
- Meaning
- Diagnosis of thalassemia and hemoglobinopathy
Clinical significance of hemoglobin electrophoresis
- Hemoglobin electrophoresis analysis is suitable for the diagnosis of thalassemia and some hemoglobin diseases. Hemoglobin electrophoresis plays a very important role in the screening of thalassemia. Able to quantitatively detect the contents of hemoglobin A (HbA), hemoglobin F (HbF), and hemoglobin A 2 (HbA 2 ). It can be used to preliminarily classify thalassemia into alpha thalassemia or beta thalassemia, which can effectively screen out high-risk couples Is the same type of thalassemia), and can also screen for various abnormal hemoglobin, such as hemoglobin H (HbH), hemoglobin E (HbE), hemoglobin G (HbG), etc., which can help clinical diagnosis, for further genetic diagnosis and Genetic counseling provides the basis.
Normal range of hemoglobin electrophoresis
- 1. Adults: HbA 96.5%; HbF <2.0%; HbA 2 3.5%.
- 2. Newborn: HbF: 60% ~ 93%; HbA 2 <1%.
- 3. Infants: 2 months: HbF <50%; 4 months: HbF <10%; 6 months: HbF <2%.