What Is Heterotopic Ossification?


Heterotopic ossification

Heterotopic Ossification Baidu Business Card

Heterotopic ossification refers to the appearance of osteoblasts in soft tissue and the formation of bone tissue. Mostly occur around large joints, such as the hip, elbow, etc. Common in patients with neurological palsy. The pathogenesis is unclear. Predisposing factors may be neurological and bioelectrical factors. There was obvious local swelling and pain in the early stage, and joint movement was limited. In the later period, joint movement is restricted due to the formation of bone tissue. The basic pathological change is that in fibrous connective tissue, primordial cells proliferate actively with a rich capillary network, calcium salts are deposited, and bone is formed. Mature ectopic ossification has a bone structure, the outer layer is wrapped with fibrous connective tissue, which contains osteoblasts, has trabecular nodes and osteoid tissue, and the center is active primitive cells. Some people think that ectopic ossification is different from ossifying myositis. The latter refers to the tissue mechanization due to injury or bleeding of muscle tissue, forming induration and contracture. There is generally a clear history of local injury. Local pain is not necessarily obvious, but there is some degree of restricted movement. Ossifying myositis is not necessarily around the joints, but rather is concentrated in the muscles. The cause of ectopic ossification is unclear and prevention is difficult. Its occurrence may be related to hyperactive limbs in the early stages of injury. Once ectopic ossification occurs, in principle, early thermal treatment, ultrasound, and massage of the affected area should be avoided. Slow, gentle movements prevent contractures. Progressive exercise should be used, and improper treatment can increase ossification. Currently, the effective drug for preventing ectopic ossification is Didronel (Etridronate disodium).

Ectopic ossification

This medicine has the properties of pyrophosphate that regulates the biological effects of ossification, and can prevent calcification of soft tissues in vivo. It has been reported that the traditional Chinese medicine for promoting blood circulation, removing blood stasis and swelling, and dampening and dissolving collaterals can reduce ossification and promote inflammation absorption and calcification. Removal of ossification that impedes activity must be waited for 9-12 months or until the ossification has matured and the ossification has stopped. Didronel can still be used after surgery for about one year.

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