What Is Magnesium Gluconate?

Magnesium gluconate (chemical formula: MgC12H22O14) is a magnesium salt of gluconic acid. White or off-white odorless fine powder. Dissolved in water. It is obtained by dissolving magnesium oxide or magnesium carbonate in gluconic acid. Used as nutritional supplements, buffers, curing agents, etc.

Magnesium gluconate (chemical formula: MgC12H22O14) is a magnesium salt of gluconic acid. White or off-white odorless fine powder. Dissolved in water. It is obtained by dissolving magnesium oxide or magnesium carbonate in gluconic acid. Used as nutritional supplements, buffers, curing agents, etc.

Brief introduction of magnesium gluconate compounds

Magnesium gluconate (chemical formula: MgC12H22O14) is a magnesium salt of gluconic acid. White or off-white odorless fine powder. Dissolved in water. It is obtained by dissolving magnesium oxide or magnesium carbonate in gluconic acid. Used as nutritional supplements, buffers, curing agents, etc.

Basic information about magnesium gluconate

Chinese name: Magnesium gluconate

English name: Magnesium Gluconate

CAS number: 3632-91-5

Molecular formula: C ₁₂ H ₂₂ MgO ₁₄

Chemical structure:

Molecular weight: 414.60000

Exact mass: 414.08600

PSA: 254.90000

LogP: -7.14040

Physicochemical properties of magnesium gluconate

Density: 1.763g / cm ³

Melting point: 131ºC

Boiling point: 673.6ºC at 760 mmHg

Flash point: 375.2ºC ^[1]

Toxicological data of magnesium gluconate

Acute toxicity: mouse intravenous LD50: 321 mg / kg

Calcium Chemical Data for Magnesium Gluconate

1. Number of hydrogen-bonded donors: 10

2. Number of hydrogen bond acceptors: 14

3. Number of rotatable chemical bonds: 8

4. Topological molecular polar surface area (TPSA): 283

5. Number of heavy atoms: 27

6. Surface charge: 0

7. Complexity: 165

8. Number of isotope atoms: 0

9. Determine the number of atomic stereocenters: 8

10. Uncertain number of atomic stereocenters: 0

11, determine the number of chemical bond stereocenters: 0

12. Uncertain number of chemical bond stereocenters: 0

13. Number of covalent bond units: 3 ^[2]

Method for synthesizing magnesium gluconate

1000 mL of a 25% aqueous gluconic acid solution was heated to boiling, and solid magnesium carbonate powder was added in portions under constant stirring until the pH of the solution remained close to 7, and stirred for a while to complete the reaction. Then add an appropriate amount of activated carbon to decolorize. Suction filtration while hot. After the filtrate was slightly cold, an equal volume of 95% ethanol was added, and a large amount of white magnesium gluconate solid precipitated immediately. After filtration, the product was dried under vacuum below 100 ° C to obtain a product with two crystal waters. ^[2]

Magnesium gluconate drug analysis

Magnesium gluconate

This product is white or off-white powder, odorless and almost tasteless. This product is hygroscopic. Soluble in water, slightly soluble in absolute ethanol or chloroform.

Identification of magnesium gluconate

(1) Take about 0.5g of this product into a test tube, add 5ml of water to dissolve. Add 0.7 ml of glacial acetic acid and 1 ml of freshly distilled phenylhydrazine, heat on a water bath for 30 minutes, and then let it cool. Rub the inner wall of the test tube with a glass rod to gradually form yellow crystals.

(2) Take about 0.1g of this product, add 5ml of water to dissolve it, add 1 drop of ferric chloride test solution to show a dark yellow color.

(3) Take about 0.1g of this product, add 1ml of water to dissolve, add a little ammonium chloride, and neutralize with ammonium carbonate reagent.

Magnesium gluconate information

Pharmacological action of magnesium gluconate

This product can increase the blood magnesium concentration and maintain the blood magnesium concentration after intravenous drip of magnesium sulfate by oral administration. It is used for the treatment of pregnancy-induced hypertension syndrome.

Pharmacology and Toxicology of Magnesium Gluconate

Magnesium gluconate dissociates into magnesium ions and gluconic acid in the body, participates in all energy metabolism in the body, activates or catalyzes more than 300 enzyme systems. The synthesis of DNA and RNA, as well as the structure of cell membranes, is indispensable for magnesium ions. This product has obvious muscle relaxation effect, can relieve coronary artery spasm, reduce the release of acetylcholine, maintain the balance of potassium and magnesium ions in the body, can prevent platelet aggregation and coronary thrombosis caused by magnesium deficiency, and has calcium resistance And membrane stabilization.

Pharmacokinetics of magnesium gluconate

This product is produced from glucose in vitro and its absorption pathway is the same as glucose. Absorption begins within 1 hour and continues at a constant rate to 8 hours. It may be absorbed faster and more completely when starved. The biggest feature of this product is that the absorption and digestion of chelated cations are far better than other types, and all age groups can be well absorbed by the gastrointestinal tract. The absorbed magnesium is mainly excreted by the kidneys.

Magnesium gluconate dosage form and specifications

1. Magnesium gluconate particles: 5g: 3g (based on anhydrous magnesium gluconate); 2. Oral solution of magnesium gluconate: 10ml: 1000mg (equivalent to 58.6mg of magnesium element).

Magnesium gluconate indication

For various reasons of magnesium deficiency or hypomagnesemia.

Contraindications to magnesium gluconate

(1) Patients with renal insufficiency, hypotension, and respiratory depression are disabled.

(2) Those with urine volume <100ml / 4 hours are forbidden.

(3) Breathing <16 beats / min. Those who have disappeared the knee tendon reflex are disabled.

Precautions for magnesium gluconate

(1) This medicine should be used under the guidance of a doctor, avoiding combination with central nervous system inhibitors.

(2) If diarrhea occurs after taking this product, the dose should be reduced or discontinued as appropriate.

(3) Respiratory and knee tendon reflexes should be checked before each medication. If respiration is less than 16 breaths per minute and knee tendon reflexes disappear, stop using this product.

Magnesium gluconate for pregnant and lactating women

Use under the guidance of a doctor.

Adverse reactions of magnesium gluconate

No serious adverse reactions. Individual patients have diarrhea, and taking it after meals or in divided doses has a certain effect on reducing gastrointestinal symptoms.

Magnesium gluconate

Take it orally, as directed by a doctor. Each bag is dissolved with about 100 ml of warm boiling water and taken orally; 5-10g (1-2 bags) each morning and evening, or according to the doctor's advice, adjust the dose according to the condition.

Magnesium gluconate storage

Sealed and stored in a dry place. ^[3-4]