Why Is Bacterial Resistance to Ampicillin a Concern?

Drug-resistant bacteria are drug-resistant pathogens. The microorganisms that have developed tolerance to the corresponding antibiotics after long-term antibiotic selection are collectively referred to as drug-resistant bacteria. The so-called bacterial resistance refers to the reduction or even disappearance of the susceptibility of the drug to the drug after repeated contact with the drug, resulting in a decrease or even ineffectiveness of the drug against the drug-resistant bacteria. The emergence of drug-resistant bacteria increases the difficulty of curing infectious diseases and forces humans to find new ways to fight microbial infections.

Drug-resistant bacteria are mainly caused by the irrational use of antibiotics ^[1]

In the 1950s and 1960s, known as the "golden age" of antibiotics, the world

Like other organisms in nature, the genes of bacteria are randomly mutated in evolution. Antibiotic-sensitive bacteria are killed, and

The abuse of antibiotics is the main reason for the large number of resistant bacteria. Before 1993, the United States issued 70 million prescriptions containing antibiotics every day, and antibiotics were almost always used for diseases suspected of bacterial infection. Colds, enteritis,

In China, the abuse of antibiotics is also very common. According to surveys, about 75% of outpatients with colds in China use antibiotics, and surgery

Common clinical MDROs include methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococcus (VRE), extended-spectrum beta-lactamase (ESBLs), and enterobacteriaceae (such as Escherichia coli and pneumonia). Klebsiella), Carbapenem-resistant Enterobacteriaceae, Multidrug-resistant Pseudomonas aeruginosa (MDR-PA), Multidrug-resistant Acinetobacter baumannii (MDR-AB), etc. ^[2]

1. Strengthen the standardized construction of clinical microbiology (department) departments, and improve the ability, efficiency and accuracy of pathogenic diagnosis. Equip with corresponding equipment and professional and technical personnel, strengthen training, improve diagnostic methods, formulate various laboratory guidelines, and improve the level of pathogenic diagnosis and detection of drug-resistant bacteria.

2. The hospital strictly implements the disinfection and isolation system to prevent cross-infection of drug-resistant bacteria in the hospital. Strictly implement sanitary management, strengthen aseptic operation, disinfection and isolation and control of drug-resistant bacteria in hospitals, reduce the incidence of hospital infections, and correct the concept and medical behavior of over-reliance on antibacterial drugs to prevent infections ^[3] .