What Are Acetylcholine Receptor Antibodies?

There are two types of acetylcholine receptors: muscarinic receptors (M receptor-G protein coupled receptors) and nicotinic receptors (N receptors-ion channel receptors). Anti-acetylcholine receptor antibody (AchR-Ab) is an autoantibody in the serum of patients with myasthenia gravis. AchR-Ab is a polyclonal antibody, most of which belong to the anti--silina snake toxin binding part, mainly IgG type, IgM type can also be detected, and serum AchR-Ab of different types of myasthenia gravis patients have different nature. The detection method of AchR-Ab was firstly used immunoprecipitation method and ConA-Sepharose method. In order to avoid the use of isotopes, enzyme-linked immunoassay was developed at the historic moment.