What Is a Blocking Antibody?

In the serum of normal pregnant women, there is a specific IgG antibody against spousal lymphocytes, which can inhibit lymphocyte response, block the cytotoxic effect of maternal lymphocytes on the embryonic trophoblast, and prevent helper T cells from recognizing inhibitors of fetal antigen And can prevent the mother's immune system from attacking the embryo. Blocking alloantigen-stimulated lymphocytes produces macrophage migration inhibitory factors, so it is called blocking antibody (BA).

Basic Information

Chinese name

Blocking antibody

Clinical significance

Repeated spontaneous abortion assessment

Reference

Cytotoxicity index <20% is negative

Clinical significance of blocking antibodies

The occurrence of recurrent spontaneous abortion is related to the lack of blocking antibodies in the mother. The more the number of abortions, the greater the possibility of lack of blocking antibodies in the body. The patient lacks blocking antibodies against the spouses CD3, CD4, and CD8 antigens, and the mother has strong rejection of the fetus. Recurrent spontaneous abortion can occur in the first trimester of pregnancy, hypertensive disorders of pregnancy can occur in the third trimester, and fetal intrauterine growth restriction , And even appeared in the fetal death palace. Therefore, it is necessary to perform APLA testing on patients with recurrent spontaneous abortion.

Blocking antibody reference value

Cytotoxicity index> 20% is positive for blocking antibodies, and cytotoxicity index <20% is negative for blocking antibodies.