What Is a Mucin?
Mucoprotein (mucoprotein) is a type of glycoprotein mainly composed of mucopolysaccharides, which is commonly found in synovial fluid of the knee. Mucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates are usually produced in the epithelial tissue of most organisms). The key feature of mucins is their ability to form gels; therefore they are a key component of most gelatinous secretions, providing lubrication, cellular signaling pathways, and chemical barrier functions.
Mucin
- At least 20 human mucin genes have been distinguished by their clones-
- Mature mucin is composed of two different regions:
- Amino and
- Mucin
- After stimulation, MARCKS (myristoylated alanine-rich protein kinase C substrate) protein coordinates secretion of mucin from mucin
- Increased mucin production occurs in many adenocarcinomas, including pancreatic, lung, breast, ovarian, colon, and other tissues. Mucin is also overexpressed in lung diseases such as asthma, bronchitis, chronic obstructive pulmonary disease or cystic fibrosis. Two membrane mucins, MUC1 and MUC4 have been extensively studied relative to their pathological implications during disease processes. Mucins are being investigated as much as possible during the diagnosis of malignancies and other diseases, and they are most often over- or mis-expressed.
- The abnormal deposition of mucin is responsible for non-depressed facial edema seen in untreated hypothryoidism. This edema will also be in the anterior tibial area.
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