What Is Calcium Homeostasis?
In the regulation of cell functions, Ca2 + can play a key role in signal transduction as a second messenger. At the same time, Ca2 + is also one of the activation molecules of a variety of enzymes involved in the breakdown of proteins, phospholipids and nucleic acids.
Intracellular calcium homeostasis
Right!
- Chinese name
- Intracellular calcium homeostasis
- Ca2 +
- The key role of signaling
- Attributes
- One of the activating molecules
- Function
- Sustained elevated calcium may activate various tissues
- In the regulation of cell functions, Ca2 + can play a key role in signal transduction as a second messenger. At the same time, Ca2 + is also one of the activation molecules of a variety of enzymes involved in the breakdown of proteins, phospholipids and nucleic acids.
- Under normal circumstances, intracellular calcium homeostasis is controlled by the co-operation of plasma membrane Ca2 + transposase and intracellular calcium pool system. When the cell is damaged, this manipulation process disorder can lead to an increase in Ca2 + influx, the release of Ca2 + from the intracellular storage site and / or inhibition of expulsion through the plasma membrane, resulting in an uncontrollable increase in the intracellular Ca2 + concentration and a continuous intracellular Ca2 + concentration Above the physiological level will inevitably lead to the uncontrollable destruction of important macromolecules that maintain cell structure and function. And this continuous increase will completely destroy the transient Ca2 + concentration transients caused by the stimulation of hormones and growth factors necessary for normal life activities, endanger mitochondrial function and cytoskeleton structure, and finally activate the irreversible catabolism of intracellular components. .
- Toxins can interfere with the transmission of cellular signals at different levels, leading to the loss of the normal response of intracellular Ca2 + to hormones and growth factors. In addition, abnormal activation of the calcium signaling system is also an important mechanism for cell death caused by toxicants.
- At present, intracellular calcium homeostasis is the hottest topic in cell damage and mechanism research. A large amount of evidence indicates that the continuous increase of cellular calcium may activate various toxic mechanisms of various tissues and cells, so it was once called "cell death The ultimate common approach. "