In Science, What Is Epigenesis?

This book mainly explains the basic concepts of epigenetics, its development history, epigenetic phenomena and their molecular mechanisms, and makes extensive use of epigenetics in biomedicine and techniques commonly used in epigenetic research. System introduction. The publishing house is Shanghai Science and Technology Publishing Company.

Epigenetics: Principle Technology and Practice

The book is divided into 22 chapters, mainly including the structure and function of chromatin, regulation of gene expression in eukaryotic cells, epigenetic phenomena, DNA methylation, histone modification, chromatin remodeling, chromatin compartmentalization, and spacer And gene cluster regulation, siRNA and miRNA-mediated regulation, regulation of gene expression by nuclear matrix molecules, epigenetic regulation during disease formation, epigenetics of cancer, epigenetic regulation in the immune system, individual occurrence Epigenetics, epigenetics and evolution, epigenetics and aging, epigenetics of cell differentiation, epigenetics and stem cells, epigenetics and environment, epigenetics and genes Therapy, plant epigenetics, epigenetics research techniques, etc.

This book can be used by comrades engaged in life science research as an introductory reference book for studying epigenetics, and can also be used as a graduate textbook for genetics in colleges and universities.

Chapter One Introduction

Challenges to the completion of the first human genome project

Development History of Epigenetics

Section 3 Research Content of Epigenetics

Section 4 Epigenetics and Genetics

Section 5: The Impact of Epigenetics on Medicine

Section 6 International Human Epigenomic Project

Chapter 2 Structure and Function of Chromatin

Section 1 Structure and Function of Nucleus

Nucleosome

Structure and Remodeling of Chromatin

Section IV Chromosome

Nucleolar dynamics

Chapter III Regulation of Gene Expression in Eukaryotic Cells

Section 1 Gene Structure

Section 2 Transcriptional Regulation

Section III Post-transcriptional RNA processing

Section IV Regulation of Translation Initiation and Post-translation

Chapter 4 Epigenetic Phenomenon

DNA methylation

Section 2 Genetic Imprint

X chromosome inactivation

Section 4 RNA Regulation

Section 5. Transposable elements as epigenetic signals

Section 6 Other epigenetic phenomena

Chapter 5 DNA Methylation

DNA methylation

DNA methyltransferases of eukaryotes

Section III DNA Demethylation

Section 4 DNA methyltransferase inhibitors

The relationship between DNA methylation and other epigenetic modifications

Chapter 6 Histone Modifications

Histone acetylation and deacetylation

Histone methylation modification

Histone phosphorylation

Histone ubiquitination

Section 5 SUMOization of Histone

Section 6 histone code

Chapter VII Remodeling of Chromatin

Positioning of nucleosomes

Hypothetical steps for chromatin remodeling

Section 3 Types and Functions of Chromatin Remodeling Complex

Section 4 Several Models of Chromatin Remodeling

Chromatin Remodeling in the Cell Cycle

Chapter 8. Chromatin compartments and isolators and gene cluster regulation

Section 1 What is chromatin compartmentalization

Section II Basic Characteristics of Isolators

Section III Mechanism of the Isolator

Chapter 9 Regulation by siRNA and miRNA

Section I RNA interference overview

Research progress on mechanism and function of siRNA

Section III Mechanism and Research Progress of miRNA

Chapter 10 Regulation of Nuclear Matrix Molecules on Gene Expression

The first section of the nuclear matrix

Function of nuclear skeleton

Regulation of gene expression by nuclear fibrous layer in the third section

Chapter XI Epigenetic Regulation During Disease Formation

Section I Epigenetics and Human Diseases

Epigenetics and Cardiovascular Diseases

Section 3 Epigenetics and Metabolic Syndrome

Chapter 12 Epigenetics of Cancer

Section 1 Cancer-Related Hypomethylation in the Human Genome

Section 2 Hypermethylation of Tumor Suppressor Genes Related to Cancer

Cancer related histone modifications

Clinical significance of epigenetics in cancer

Chapter 13 Regulation of Epigenetics in the Immune System

The first section epigenetics regulates immune cell differentiation and functional expression

Section T Cell Subpopulation Differentiation and Regulation of Corresponding Cytokine Gene

Section III Chromatin Remodeling and Regulation of Immune Gene Expression

Epigenetic regulation of co-activator and MHC expression

Chapter 14 Epigenetics in the Process of Individual Development

DNA methylation in meiosis

Origin of the genomic imprint

Formation and maintenance of genomic imprints during development

Section 4 Impact of abnormal genomic imprints on individual occurrence

Chapter 15 Epigenetics and Evolution

Epigenetic system

Cell Memory of Epigenetic Markers

Controversy over the role of epigenetics in evolution

Chapter 16 Epigenetics and Aging

Section 1 Age and Physiological Response

The molecular mechanism of regulation of age-related indicators

Epigenetics of age-related homeostasis

The fourth section research technology of age-related biological indicators

Epigenetics of Cell Differentiation

Cell differentiation

Cell differentiation potential

Epigenetics of Cell Differentiation

Epigenetic regulation of cell differentiation

Chapter 18. Epigenetics and Embryonic Stem Cells

Section 1 Introduction

Histone modifications and stem cell pluripotency

X chromosome inactivation

RNAi and stem cell differentiation

Section 5. Genomic Imprinting Status in Embryonic Stem Cells

Chapter 19 Epigenetics and the Environment

Section 1 Epigenetic Changes and Environmental Effects

Epigenetic Effects of Nickel

Section 3 Arsenic Exposure and Epigenetic Changes and Effects on Gene Expression

Epigenetic Effects of Environmental Estrogen

Section 5 Main Micronutrients and Metabolic Factors Affecting DNA Methylation

Chapter 20 Epigenetic Therapy

Section I Overview of Epigenetic Therapy

Drug targets and drugs for epigenetic therapy

Section 3 Features and Prospects of Epigenetic Therapy

Chapter 21 Plant Epigenetics

Section 1 gene silencing

Section 2 Main Modes of Apparent Regulation

Epigenetic regulation of transposable elements in plants

Section 4 Control of Gene Expression by Apparently Regulated Gene Expression of Transposable Elements

Chapter 22 Epigenetic Research Techniques

Appendix 1 Foreword

Appendix 2 Age Dimension Homeostasis: Significance and Mechanisms

Appendix 3 Epigenetics and Embryonic Stem Cells

Appendix 4 The Epigenetics of Plants

index

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