What Are Biological Response Modifiers?

Biological response modifiers (BRM), also known as biological modifiers, is a new term for immunotherapeutics. Any kind of agent or method that directly or indirectly enhances the body's anti-tumor effect through the immune system and has a therapeutic effect on tumors can be called a biological response modifier.

Biological response modifier

Right!

Biological response modifiers (BRM), also known as biological modifiers, is a new term for immunotherapeutics. Any kind of agent or method that directly or indirectly enhances the body's anti-tumor effect through the immune system and has therapeutic effects on tumors can be called a biological response modifier.

Chinese name

Biological response modifier

Foreign name

biological response modifiers, BRM

Also known as

Biological regulator

Effect

Enhance the body's antitumor effect

Biological response modifiers (BRM), also known as biological modifiers, is a new term for immunotherapeutics. Any kind of agent or method that directly or indirectly enhances the body's anti-tumor effect through the immune system and has therapeutic effects on tumors can be called a biological response modifier. Michell's definition of a biological response modifier:

1. Directly enhance host anti-tumor response, such as cytokines;

2. Reduce the inhibitory mechanism and indirectly enhance the host's anti-tumor response;

3. Enhance the host's tolerance to cytotoxic substances;

4. Change the tumor cell membrane structure to enhance its immunogenicity, or make tumor cells more sensitive to autoimmunity or anti-tumor drugs;

5. Prevent or reverse cell transformation.

These substances include drugs that enhance the body's immune function, regulate it, and restore and rebuild immune function. A variety of cytokines such as lymphokines, monocytes, tumor growth inhibitors, and thymus factors, etc .; immune-active cells such as cytotoxic T lymphocytes, lymphokine-activated killer cells (LAK cells), cytokine-activated tumor infiltrating lymphocytes (TIL cells), etc .; monoclonal antibodies, certain non-specific stimulating substances such as BCG vaccine, Corynebacterium brevis, etc. There are also chemically synthesized drugs such as levamisole. In addition, certain traditional Chinese medicines, polysaccharides (such as lentinan, Yunzhi polysaccharides, etc.) and trace elements can also promote immune function and can be used as biological regulators.

Biomodulators have multiple functions and uses. It can enhance the body's anti-tumor function, induce tumor cells to differentiate and mature into normal cells; reduce the immunosuppressive effect, increase the body's tolerance to toxic substances and directly enhance the body's defense ability, and promote the early recovery of diseases; The curative effect of radiation therapy and surgical treatment on tumors and reduce its side effects. It can also treat various viral infectious diseases such as viral hepatitis and AIDS. Although BRM therapy is currently only a preliminary exploration, the hope for cancer patients is real. These hopes will be fulfilled, when cancer is conquered.