What Are the Different Types of HPV Infections?

HPV is a causative agent of cervical cancer, and HPV typing can prevent cervical cancer.

HPV typing

Right!

HPV is causing

Currently, there are two types of reagents that provide HPV typing tests. One is to determine whether they are infected.

1. There may be differences in the types of HPV infection before and after treatment, which can be used as an evaluation index for the treatment effect of doctors.

2. Two consecutive HPV typing tests revealed a single type of high-risk subtype infection, showing

Cervical cancer is the second most common cause of cancer and mortality among women in China, with 465,000 new cancers each year. Studies have found that HPV can be detected in about 90% of cervical cancer patients, and high-risk HPV is closely related to cervical cancer. Li Zhao et al. Used polymerase chain reaction (PCR) to perform HPV DNA typing of 253 different cervical lesions. According to the sequence of chronic cervicitis, pseudocondyloma, wart-like lesions, condyloma acuminatum, CIN and cervical cancer, the HPV positive rate was The increasing trends are 16.7%, 29.8%, 37.5%, 61.7%, 79.7% and 90.9%, respectively. And the positive rate of HPV6 / 11 type was significantly higher in the condyloma acuminatum group and the CINI group than in the CINII-III group, while the HPV16 / 18 type was just the opposite. Yuan Liyun and other 158 patients with abnormal cervical smears underwent colposcopy cervical multipoint biopsy and cervical PCR-HPV-DNA tests. The results showed that chronic cervicitis, low-grade squamous intraepithelial lesion (LSIL), and high-grade squamous intraepithelial The HPV16 / 18 infection rates of lesions (HSIL) and cervical cancer were 8.66%, 34.69%, 68.89%, and 83.33%, respectively. The HPV16 / 18 infection rates of HSIL were significantly higher than those of LSIL (P <0.01). Jiang Qiying and other researchers applied in situ PCR (ISPCR) to detect HPV16 DNA and HPV18 DNA in 44 cases of cervical cancer, 18 cases of paracancerous tissue, 30 cases of chronic cervicitis, and 15 cases of normal cervical tissue. HPV16 DNA was positive 79.5%, HPV18 DNA was 11.3%; 15 cases of adjacent tissues were associated with CINII-III, HPV16 DNA was 80%, 1 case of HPV16 DNA was positive in the other 3 cases of adjacent cancer tissue; 30 cases of chronic cervicitis DNA positive was 13.3%; HPV DNA was negative in 15 normal cervical tissues. Yang Lingli, Shi Qing, etc. [6] analyzed the pathological results and HPV infection of 218 cervical cone resections performed in the Obstetrics and Gynecology Department of the Conception Hospital of Marseille, France from January 1, 1996 to June 30, 1998. , Similar results were obtained. In addition, Dr. Eduardo L. Franco of McGill University in Montreal, Canada, and colleagues analyzed the data of 2262 women and pointed out that women continue to be infected with HPV for a long period of time, and the risk of developing highly squamous epithelial cervical injury remains high, but The risk of low-grade SIL decreases over time. All these indicate that cervical precancerous lesions and cervical cancer are closely related to HPV infection, especially high-risk HPV infections such as HPV16 / 18, and the detection rate of HPV16 / 18 increases with the severity of the disease, suggesting that HPV16 / 18 is a cervical High risk factors for cancer. Some scholars believe that HPV52, 58 are Asian types, and the majority of patients in Japan and Hunan, Guangzhou, Hong Kong and other regions are HPV52 and 58 types.

In addition, HPV infection also affects the prognosis of cervical cancer. Chen Yile and others used in situ hybridization to measure HPV expression in each cancer tissue. As a result, among 94 patients with cervical cancer treated by surgery, chemotherapy, etc., the HPV positive rate in the group of patients who survived less than 10 years was much higher than 10 years. The above groups; compared with patients with clinical stage IIb, the HPV positive rate in patients who survived for 10 years was significantly higher than that in patients who survived for more than 10 years. This indicates that patients with cervical cancer with HPV infection have a poor prognosis.

Young and middle-aged women are at the peak of high-risk HPV infection. It is reported that the HPV infection rate of women over 20 years of age is as high as 1639 / 100,000, of which the HPV infection rate of women in the age groups of 25-30 and 30-34 years is 2000 / 10 Million. In recent years, cervical HPV infection has become younger. Shenzhen Pok Oi Hospital applied the hybrid capture method (HC-II) to HPV testing on 1898 patients who visited and surveyed in April-November 2002, and found that the difference in HPV detection rates at different ages was significant (P = 0.017); The prevalence of HPV in the group <20 years, 21-25 years, 26-30 years, 30-40 years and 40 years was 34.8%, 29.2%, 22.6%, 26.2% and 24.2%, respectively. The incidence of cervical cancer in young women has also increased significantly, increasing at a rate of 2% -3% per year. Ni Fengyun and others collected 93 patients with cervical cancer before stage IIb from 1991 to 2000. The analysis found that the incidence of cervical cancer had a significant upward trend. The last 5 years group increased by 7.9% compared with the previous 5 years group. The average age of disease was 3.6 years earlier. It is 5.1 years earlier than the traditional age of onset. HPV testing was performed in the affected women. The positive rate was 100% in the young segment and 77.8% in the middle and old segment.