What causes transplant rejection?
The rejection of transplantation is caused by the immune reaction of the body to a foreign material. Naturally, the body tries to destroy the encounter with foreign matter. As a result, those who receive transplants receive drugs to reject transplantation that reduce the body's immune response. They identify viruses and bacteria that have entered our bloodstream and begin to eliminate them tirelessly. Leukocytes help us recover from diseases and also prevent us from getting some illnesses because we have already become immune from the previous white blood cells.
But when someone receives transplantation, leukocytes work against a new organ. They immediately recognize the organ as foreign and are going to destroy it. More leukocytes are produced that deprive the body of the organ and create a battle between the new organ and white blood cells.
When white blood cells white blood cells are effective, this causes rejection of transplants. Usually transplanted organs are tested for the presence of leukocytes to measure the amount of odulling. The answer to this problem is problematic. Leukocytes must be reduced to allow a new organ to do their work.
As such, those who receive organs use immunosuppressive drugs that can prevent rejection of transplants. This results in a weakened immune system because leukocytes are not available to combat normal diseases that one could encounter. Those who receive transplantation are then more vulnerable to viruses and infections. In addition to drug rejection drugs, most of which receive transplantation often, take antibiotics or are consistent doses of prophylactic antibiotics to prevent infections.
Long -term use of antibiotics creates another problem. Bacteria tend to be resistant to antibiotics over time, ie fighting bacteria means transition to newer and stronger antibiotics. Patients can beAlso allergic to certain antibiotic classes, which limits the types of drugs that patients can take. The stronger antibiotic is also reflected in more side effects, such as frequent fungal or yeast infections, stomach angry and skin rashes.
Thus, the attempt to prevent transplants rejection requires a very fine pharmaceutical balance. One had to exclude enough leukocytes to avoid rejection of transplants, but not so much that viruses would claim the patient's life. Antibiotics must be administered to stop the infection; However, antibiotics must not be so strong that the patient dies of antibiotics resistant diseases.
In anti-rejection drugs, the rejection of transplantation is now reduced to about 10-15%. Narrowly corresponding blood types and blood factors help, but the body still "knows", the organ is not from the body. Only transplants from the same twins and the cornea are that ansplants are unrecognized leukocytes. It also seems that the valves for the heart taken from pigs, cows and deadl are not considered "foreign". Transplant rejection is often not the cause of death in patients with transplantation. The fight against the rejection of transplantation is. Complications from transplants are likely to cause death than rejection of transplantation.
However, the transplant technology field is constantly evolving. Almost all transplants were rejected suddenly. Now constant research of anti -drug anti -tide changes in the rejection of transplantation and complications from transplant drugs.
The aim of transplant experts is to reduce rejection and also to create medicines that do not cause those who receive transplantation suffer from life -threatening complications. When this goal is achieved, medical fields can certainly require victory.