What Is a Sex Hormone Binding Globulin?

Sex hormone-binding globulin (SHBG), also known as testosterone-estradiol binding globulin, is a carrier of sex hormones. It changes during the action of sex hormones and under various physiological and pathological conditions. And meaning.

Sex hormone binding globulin

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Sex hormone-binding globulin (SHBG), also known as testosterone-estradiol binding globulin, is a carrier of sex hormones. It changes during the action of sex hormones and under various physiological and pathological conditions. And meaning.
Chinese name
Sex hormone binding globulin
Foreign name
sex hormone-binding globulin, SHBG
Function
Sex hormone carrier
nickname
Testosterone-estradiol-binding globulin
In hormone-binding testosterone, 44% -60% of sex hormone-binding globulin binds to SHBG; estrogen binds to specific SHBG in about 95% of blood circulation.
Clinical application [1] :
1. Female hirsutism and virilizing SHBG content In female hirsutism and virilizing disease, the content is only 50% of the normal value, and the free T content is almost 90%. Therefore, the determination of SHBG in such diseases can be used not only as a diagnostic indicator, but also as a basis for measuring the effect of treatment.
2. Polycystic ovary syndrome, obesity, hypothyroidism, and decreased SHBG levels.
3, male hypogonadism, SHBG levels increase, and plasma T levels are often normal. During hyperthyroidism, SHBG levels rise.
4, liver disease: liver cirrhosis, chronic hepatitis, fatty liver SHBG levels increased.
5. Serum sex hormone binding globulin increases in premature breasts. The experimental results show that the increase of SHBG in premature breasts is due to the low bioactive testosterone, which changes the estrogen / androgen ratio in breast tissue.

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