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A chemical agent, menthol is extracted from the leaves and stems of mint, with white crystals and molecular formula C ₁₀ H ₂₀ O. It is the main component of essential oils of peppermint and peppermint. In the world, India is a major producer of natural mint. Both menthol and racemic menthol can be used as flavoring agents for toothpaste; perfumes; beverages and candy. It is used as a stimulant in medicine, acting on the skin or mucous membranes, and has a cooling and antipruritic effect. Oral administration can be used as a wind repellent for headaches and noses; Its esters are used in perfumes and medicines.

Chinese name: mint brain

Chinese alias: (+/-)-menthol; menthol; 2-isopropyl-5-methylcyclohexanol; hexahydrothymol;

English name: DL-Menthol

English alias: Menthomenthol; 2-isopropyl-5-methyl-cyclohexanol;

CAS number: 89-78-1

Molecular formula: C ₁₀ H ₂₀ O

Molecular weight: 156.26500

Exact mass: 156.15100

PSA: 20.23000

LogP: 2.43950 ^[1]

CAS number: 89-78-1

MDL number: MFCD00001484

EINECS number: 201-939-0

RTECS number: OT0350000

BRN number: 1902288

PubChem number: 24901226 ^[1]

Customs code: 2906110000

Dangerous Goods Transport Code: UN 1888 6.1 / PG 3

WGK Germany: 2

Danger category code: R36 / 37/38

Safety instructions: S36 / 37 / 39-S24 / 25-S36-S26

RTECS number: OT0350000

Dangerous goods mark: Xi ^[1]

This product is a saturated cyclic alcohol obtained from mint oil. Aka

1. Molar refractive index: 47.83

2. Molar volume (cm ³ / mol): 175.5

3. Isotonic specific volume (90.2K): 409.8

4. Surface tension (dyne / cm): 29.7

5. Polarizability (10 ^-24 cm ³ ): 18.96 ^[1]

1. Reference value for calculation of hydrophobic parameters (XlogP): 3

2. Number of hydrogen-bonded donors: 1

3. Number of hydrogen bond acceptors: 1

4. Number of rotatable chemical bonds: 1

5. Number of tautomers:

6. Topological molecular polar surface area (TPSA): 20.2

7. Number of heavy atoms: 11

8. Surface charge: 0

9. Complexity: 120

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 3

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Uncertain number of chemical bond stereocenters: 0

15. Number of covalent bond units: 1 ^[1]

1. Left-handed is colorless needle-like crystal. Soluble in ethanol and miscible with oils. Has a cool, fresh, pleasant mint characteristic aroma, with sweet spiked gas. It gives a cold feeling, the aroma is radiant, but not long lasting. The taste is also fresh, sweet and cool.

2. Exist in flue-cured tobacco leaves, spiced tobacco leaves, and mainstream smoke.

3. Naturally present in peppermint oil, Japanese peppermint oil, and a small amount in essential oils such as gerbera oil.

4. There are 12 isomers.

5. The surface of ordinary crystals has traces of liquid oil and traces of non-volatile matter. Synthetic menthol is a mixture of various isomers.

6. Have certain toxic, irritating and allergic reactions. ^[2]

This product should be sealed and stored in a cool place. ^[1]

1. Both menthol and racemic menthol are used as flavoring agents for toothpaste, perfume, beverages, and candy. It is used as a stimulant in medicine, acting on the skin or mucous membranes, and has a cooling and antipruritic effect. Oral administration can be used as a wind repellent for headaches and inflammation of the nose, throat, and throat. Its esters are used in perfumes and medicines. In the world, China and Brazil are the main natural mint production gardens, and the annual output of peppermint oil reaches 2000-3000t.

2. Widely used in daily flavor, edible flavor, tobacco flavor. Generally 1100mg / kg in chewing gum; 400mg / kg in candy; 130mg / kg in baked goods; 68mg / kg of ice cream; 35mg / kg in soft drinks.

3. It has bactericidal and antiseptic effects.

4. Used as a special additive for curative cosmetics. Used for toilet water. It can also be used as a flavoring agent for toothpaste, perfume, beverages and candy. Used in making candy, beverages, spices and medicinal products. ^[2]

Industrially extracted from mint

(1) Take 1g of this product, add 20ml sulfuric acid to dissolve, it will be orange-red, 24 hours later, a colorless oil layer without menthol aroma (and

[Pharmacological action] This product forms a conjugate with glucuronic acid and is excreted in urine and bile. Various isomers are combined with glucuronic acid in different amounts. Produces molecular degradation reactions in dogs and rats. It can exist as a menthol metabolite.

[Properties] This product is very soluble in ethanol, chloroform, liquid paraffin or volatile oil, and slightly soluble in water.

Specific rotation: Take this product precisely weighed, add ethanol to make 0.1g dissolved in 1ml, measured according to law, specific rotation is -49 degrees to -50 degrees.

[Indications] Topical use for local pain relief, itching, headache, dizziness, mosquito bites; nasal drops for congestive nasal congestion, inhalation or spray for pharyngitis; oral administration can strengthen the stomach.

[Drug interaction] It is often combined with camphor to enhance the antipruritic effect.

[Usage and Dosage] The external rash is applied to the itchy skin and can be used multiple times a day. 0.02 0.1g, take more tablets. Or use tinctures, ointments, and apply the affected area topically.

[Formulations and specifications] menthol powder, ointment and tincture: 1% to 2%.

[Adverse reactions] Occasionally local irritation.

[Contraindications] Forbidden for infants and young children.

[Storage] Sealed and kept in a cool place.

[Poisoning First Aid] Because menthol has irritating effects on the skin and eyes and certain toxicity, you must wear gloves and safety glasses when using in large quantities. 1. Inhalation: Transfer the poisoned person to a ventilated place and take general emergency measures.

2. Stray into the eyes: Flush the eyes according to the general procedure. If necessary, please consult your doctor.

3. Skin contact: Wash with water and soap.

4. Other: Consult a physician. ^[2]

Precautions

Do not use on eyes and mucous membranes. The lethal dose of subcutaneous injection in rats is about 2g / kg body weight. It is dangerous to use nasal drops or ointment containing this product in the nasal cavity of young children, which will cause collapse.