What Is Ceruloplasmin?

Ceruloplasmin (CER), also called copper oxidase, is a copper-containing 2 glycoprotein with a molecular weight of about 120,000 to 160,000, which is difficult to purify. It is a single-chain polypeptide containing 6-7 copper atoms per molecule. It is blue due to copper and contains about 10% sugar. The terminal sialic acid is linked to the polypeptide chain and has genetic polymorphism. Its role is to regulate the distribution of copper in various parts of the body, to synthesize copper-containing enzyme proteins, to act as an antioxidant, to have oxidase activity, and to catalyze the oxidation of polyphenols and polyamines. It is generally believed that ceruloplasmin is synthesized by the liver, part of which is excreted by the biliary tract, and its content in urine is very small. The determination of aeruginin has certain significance for the diagnosis of certain liver, gallbladder, kidney and other diseases.

Aeruginin

Ceruloplasmin (CER)

Plasma ceruloplasmin (CP) normal value

Immunodiffusion method:

Newborn: 10 300mg / L (1 30mg / dl).

6 months to 1 year: 150 to 500 mg / L (15 to 50 mg / dl).

1 to 12 years: 300 to 650 mg / L (30 to 65 mg / dl).

> 12 years old: 150 600mg / L (15 60mg / dl).

Urine: 6 40g / 24h.

Clinical significance of plasma ceruloplasmin (CP)

(1) Increase:

Severe infection: inflammation, hepatitis, periostitis, pyelonephritis, tuberculosis, pneumoconiosis, etc.

Malignant tumor: leukemia, malignant lymphoma, various cancers.

Bile stasis: Primary biliary stasis type cirrhosis, extrahepatic obstructive jaundice, acute hepatitis, chronic hepatitis, alcoholic cirrhosis.

Hyperthyroidism, rheumatism, rheumatoid arthritis, aplastic anemia, myocardial infarction, after surgery, etc.

Others: acute schizophrenia, tremor delirium, homocystinuria.

Under physiological conditions, pregnancy, oral contraceptives, CER can also increase.

There is no consensus on the changes of ceruloplasmin during chronic hepatitis and cirrhosis. In theory, the blood concentration of liver cells should be reduced when liver cells are damaged. One case decreased, but nearly half of the cases increased, which is very different from the case of hepatolenticular degeneration.

It is helpful to distinguish liver cirrhosis and liver cancer. The probability of serum ceruloplasmin higher than normal in primary liver cancer is> 8.3%, and the probability of higher than normal in cirrhosis is 12%.

(2) Reduce:

Wilson disease is hepatolenticular degeneration (the most valuable diagnostic indicator).

Malnutrition: nephrotic syndrome, malabsorption syndrome, protein leakage gastrointestinal disorder, nephrotic syndrome, hypoproteinemia, etc.

Primary biliary cirrhosis, primary biliary atresia, etc.

Newborns and immature children.

seen in severe hypoproteinemia, nephrotic syndrome and so on.

Diagnosing hepatolenticular degeneration: The ceruloplasmin is significantly reduced during the disease, which may be caused by excessive deposition of copper in the liver and basal nucleus, or ceruloplasmin synthesis disorders.